James (hamstring) suffered a setback in his recovery and will likely miss Sunday's game against the Rams, Eric Smith of the Chargers' official site reports.
James is a candidate for injured reserve and could be out for some time with a persistent hamstring injury. The star strong safety has also been discussed in trade rumors as the 0-6 Chargers' season appears to be all but over. Tony Jefferson is set to start at strong safety in Sunday's game against the Rams.