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The Astros' Framber Valdez takes the mound for the first time since throwing a no-hitter against the Guardians when he faces the American League-leading Baltimore Orioles on Tuesday at Oriole Park at Camden Yards in Baltimore. One week ago, Valdez (9-7, 3.07 ERA) allowed only one walk while no-hitting Cleveland on just 93 pitches. On Tuesday, he squares off against Baltimore's Grayson Rodriguez (2-3, 6.09). Houston is a -130 favorite (risk $130 to win $100) in the latest Astros vs. Orioles odds, while Baltimore is a +110 underdog. The over/under for runs scored is 8.5.

The game is one of 16 on the MLB schedule for Tuesday. Elsewhere in the majors, the Rangers put their seven-game winning streak on the line against the A's, and the Phillies and Nationals play a doubleheader in Philadelphia. Before locking in any MLB picks or parlays, be sure to check out the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times. It went 331-285 on top-rated MLB money-line picks (+357) over the past two seasons. It entered Week 20 of the 2023 MLB season 54-43 on all top-rated MLB picks this season and has excelled on top-rated run-line picks, going 11-4 (+404). Anybody following the model has seen big returns.

For Tuesday, the model has locked in three confident MLB best bets for games that begin at 6:40 p.m. ET or later. If you successfully parlay the picks, you'd be looking at a payout of more than 8-1. You can only see the model's MLB picks at SportsLine. 

Top MLB picks today

After simulating every game on Tuesday 10,000 times, the model is taking the Reds (+114) to beat the Marlins. The Reds (60-55) enter the game holding the third and final Wild Card spot in the National League, one game ahead of the Cubs and 1.5 games ahead of the Marlins. On Tuesday, Cincinnati faces a Miami team that has been struggling. The Marlins have dropped five in a row and 17 of their last 22 since the All-Star break.

In addition, Miami starter Braxton Garrett (5-3, 4.14 ERA) does not have a history of success against the Reds. In three career starts against Cincinnati, he is 0-2 with a 4.60 ERA. Meanwhile, Reds starter Luke Weaver had one of his best starts of the season against the Marlins, allowing only one run in 5.1 innings while striking out six on May 14. See the model's top MLB picks here.

How to make Tuesday MLB parlays

The model also locked in two other best bets for Tuesday, including a play on an even bigger NL underdog, which would pay plus-money. You can see the model's MLB Tuesday best bets and parlay only at SportsLine.

What MLB picks should you target for a payout of more than 8-1, and which NL underdog should you be all over on Tuesday? Visit SportsLine now to see the MLB best bets from an advanced model that is 54-43 on all top-rated MLB picks this season, and find out.