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After falling short in last year's World Series, a 4-2 loss to the Atlanta Braves, the Houston Astros look for redemption starting on Friday when they take on the Philadelphia Phillies in Game 1 of the 2022 World Series. The Astros (106-56), AL champions for the third time in the past four years, will be looking to win their second title in six seasons, last winning it all in 2017 when they outlasted the Los Angeles Dodgers in seven games. The Phillies (87-75), who are making their first World Series appearance since 2009, are looking for their third championship and first since 2008. Justin Verlander (18-4, 1.75 ERA in regular season) will start for Houston, while Aaron Nola (11-13, 3.25 ERA) gets the call for Philadelphia in Game 1. 

First pitch is set for 8:03 p.m. ET from Minute Maid Park in Houston. Houston is a -170 favorite (risk $170 to win $100) on the money line in the latest Phillies vs. Astros odds from Caesars Sportsbook, while the over-under for total runs scored is 6.5. Before making any Astros vs. Phillies picks, check out the latest MLB predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it enters the 2022 World Series on a 20-13 roll on top-rated MLB money-line picks, returning more than $400. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen huge returns.

Now, the model has dialed in on Astros vs. Phillies and just revealed its coveted World Series 2022 picks and predictions. You can visit SportsLine now to see the model's MLB picks. Here are the MLB odds and World Series betting lines for Phillies vs. Astros:

  • Astros vs. Phillies money line: Philadelphia +143, Houston -170
  • Astros vs. Phillies over-under: 6.5 runs
  • Astros vs. Phillies run line: Houston -1.5 (+140)
  • PHI: The Phillies are 44-43 on the road this season
  • HOU: The Astros are 59-26 at home in 2022
  • Astros vs. Phillies picks: See picks at SportsLine

Why you should back the Astros 

One of Houston's most steady performers this season has been left fielder Kyle Tucker. Although he had just two hits in the ALCS sweep over the New York Yankees, he hit .267 with a homer in the ALDS sweep over the Seattle Mariners. He hit .257 during the regular season with 30 home runs, 107 RBI and 71 runs scored. In three career games against Philadelphia, Tucker has a homer and three RBI. He also hits well in his home park, batting .275 with 44 doubles, six triples, 32 homers and 120 RBI in 203 games.

Also powering the Astros is third baseman Alex Bregman, who has been on fire during the postseason. He destroyed Yankees pitching in the ALCS by going 5-for-12 with a double, homer and four RBI, and has hits in six of seven playoff games. During the regular season, Bregman was one of Houston's top hitters, batting .259 with 23 homers, 93 RBI and 93 runs scored. He has also fared well in limited appearances against Philadelphia. In five career games vs. the Phillies, he is hitting .400 with two doubles, one triple, one homer and two RBI.

Why you should back the Phillies

Third baseman Alec Bohm put together a solid season for Philadelphia, hitting .280 with 13 homers, 72 RBI and 78 runs scored. The third-year veteran also posted a .713 OPS. Bohm was a key contributor in Game 3 of the NLCS against the Padres, going 2-for-3 with a double and an RBI to help lead the Phillies to a 4-2 victory and 2-1 lead in the series. He has played well on the road. In 78 games away from home, Bohm hit .269 with 12 doubles, one triple, seven homers and 25 RBI.

Bryce Harper, meanwhile, has been destroying opposing pitching in the playoffs and in the games leading up to them. Harper has a 10-game hitting streak and has hits in 13 of his last 14 games. After hitting .286 in the Wild Card round against St. Louis, he hit .500 in the NLDS against Atlanta. Against the Padres in the NLCS, he batted .400, and delivered a powerful performance in Game 5, going 2-for-4 with a homer, two RBI and one run scored.

How to make Phillies vs. Astros picks

SportsLine's model is leaning Over on the total, projecting 7.6 combined runs. It also says one side of the money line has all the value. You can only get the model's World Series Game 1 pick at SportsLine. 

So who wins Astros vs. Phillies World Series Game 1? And which side of the money line has all the value? Visit SportsLine now to see which side of the Phillies vs. Astros money line to jump on, all from the advanced model that is on a 20-13 roll on top-rated MLB money-line picks, and find out.