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The Philadelphia Phillies will try to take a commanding 2-0 lead in the 2022 World Series when they face the Houston Astros in Game 2 of the Fall Classic on Saturday night. Philadelphia erased a 5-0 deficit in Game 1 on Friday, eventually scoring the winning run in the top of the 10th inning. Right-handed pitcher Zack Wheeler will start for Philadelphia, while left-hander Framber Valdez is going to start for Houston.

First pitch at Minute Maid Park is set for 8:03 p.m. ET. Houston is a -145 favorite (risk $145 to win $100) and the over/under is 7 in the latest Phillies vs. Astros odds from Caesars Sportsbook. Before making any Astros vs. Phillies picks, check out the latest MLB predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it enters the 2022 World Series on a 20-13 roll on top-rated MLB money-line picks, returning more than $400. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen huge returns.

Now, the model has dialed in on Astros vs. Phillies and just revealed its coveted World Series 2022 picks and predictions. You can visit SportsLine now to see the model's MLB picks. Here are the MLB odds and World Series betting lines for Phillies vs. Astros:

  • Astros vs. Phillies money line: Astros -145, Phillies +122
  • Astros vs. Phillies over/under: 7 runs
  • Astros vs. Phillies run line: Astros -1.5 (+158)
  • PHI: The Phillies are 79-66 with no days off between games in 2022
  • HOU: The Astros are 92-51 with no days off between games in 2022
  • Astros vs. Phillies picks: See picks at SportsLine

Why you should back the Phillies

Philadelphia was the last team to make the playoff field this year, but it has been riding a wave of momentum ever since. The Phillies have only dropped two games all postseason and are entering Game 2 of the World Series on a four-game winning streak. They have some additional steam after erasing a 5-0 deficit on Friday night, shelling Houston ace Justin Verlander for five runs between the fourth and fifth innings. Designated hitter Bryce Harper has now racked up 20 hits and five home runs this postseason, driving in 11 runs.

The Phillies have their ace on the mound in this game, as Wheeler went 12-7 with a 2.82 ERA during the regular season. He has been even better in the playoffs, going 1-1 with a 1.78 ERA. Valdez struggled in last year's World Series, posting a 19.29 ERA while allowing four home runs in just 4.2 innings. Philadelphia is being priced as an underdog on Saturday night, but it has the better pitcher and more momentum in this matchup. 

Why you should back the Astros

Valdez takes the ball for Houston in Game 2, and he projects to lead an outstanding run prevention unit. Valdez, a 28-year-old left-hander, was selected as a 2022 American League All-Star, and he posted a 2.82 ERA across more than 200 innings of work. Valdez has an elite ground ball rate of 66.5% this season, and he led the American League in allowing only 0.49 home runs per nine innings. 

Valdez also enters this matchup with a 1.42 ERA in 12.2 playoff innings this season, generating 15 strikeouts and three walks. Behind him, Houston will deploy arguably the best bullpen in baseball, leading MLB with a 2.80 ERA and 10.45 strikeouts per nine innings in the regular season. On the offensive side, the Astros are balanced and potent. Houston finished No. 2 in the American League in home runs and strikeout avoidance this season, with top-five AL marks in runs scored, walks, batting average, on-base percentage, OPS, doubles, slugging percentage and total bases.

How to make Phillies vs. Astros picks

SportsLine's model is leaning Over on the total, projecting 7.6 combined runs. It also says one side of the money line has all the value. You can only get the model's World Series Game 2 pick at SportsLine. 

So who wins Astros vs. Phillies World Series Game 2? And which side of the money line has all the value? Visit SportsLine now to see which side of the Phillies vs. Astros money line to jump on, all from the advanced model that is on a 20-13 roll on top-rated MLB money-line picks, and find out.