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Game 6 of the 2022 World Series on Saturday will be the first opportunity for the Houston Astros to close out the Philadelphia Phillies to win their second championship. Framber Valdez will take the ball for Houston while Zack Wheeler is Philadelphia's pick as the Phillies look to extend what has already been a magical ride through the 2022 MLB playoffs. After falling behind 2-1 in the Fall Classic 2022 while battling a Philadelphia power surge, the Astros have received two incredible pitching performances in a row and have had their bullpen give up just one run over seven innings the last two games.

Now they'll hope that Valdez can replicate a fabulous Game 2 performance with first pitch scheduled for 8:03 p.m. ET at Minute Maid Park in Houston. Caesars Sportsbook currently lists Houston as the -145 favorite (bet $145 to win $100) with Philadelphia fetching +122 as the underdog in the latest Astros vs. Phillies odds. Meanwhile, the over/under is listed at 7 runs and the Astros are -1.5 on the run line for a +150 payout. Before locking in any Phillies vs. Astros picks, be sure to see the 2022 World Series predictions from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it entered the 2022 World Series on a 20-13 roll on top-rated MLB money-line picks, returning more than $400. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen huge returns.

Now, the model has dialed in on Astros vs. Phillies and just revealed its coveted World Series 2022 picks and predictions. You can visit SportsLine now to see the model's MLB picks. Here are the MLB odds and World Series betting lines for Phillies vs. Astros:

  • Phillies vs. Astros money line: Philadelphia +122, Houston -145
  • Phillies vs. Astros over-under: 7 runs
  • Phillies vs. Astros run line: Houston -1.5 (+150)
  • PHI: The Phillies are 7-0 in their last seven games following an off day
  • HOU: The Astros are 5-0 in their last five Saturday games
  • Phillies vs. Astros picks: See picks at SportsLine

Why you should back the Astros

The starting pitchers in this matchup have been trending in opposite directions over their past few outings. Wheeler has allowed six earned runs in his last two appearances, including four against Houston in Game 2. Valdez has only allowed one earned run in his last two starts, throwing 13.1 brilliant innings against the Yankees and Phillies. He struck out nine batters in each of those games and has a ton of momentum coming into this start.

Houston has momentum as a team as well, winning consecutive road games to break Philadelphia's confidence. The core of this Houston team has experience winning the World Series, while most of Philadelphia's roster has never been in this position. The Phillies have not been nearly the same team away from home this season, going 45-44 in their road games, while Houston is 60-27 at Minute Maid Park. 

Why you should back the Phillies

After belting five home runs in Game 3 to take a 2-1 series lead, Philadelphia's bats have gone quiet over the last two games. They were no-hit by Cristian Javier and three Astros relievers in Game 4 and then only managed two runs on six hits in a Game 5 loss. However, the Phillies haven't gone more than two games in a row without scoring at least five runs in a game throughout the 2022 MLB playoffs and the league's best offense will be hoping for better fortune in Game 6.

Bryce Harper, Rhys Hoskins and Kyle Schwarber have combined to hit 17 home runs this postseason and no other team that has participated in the playoffs has combined to hit more than 16. That power can change the complexion of a game in an instant and they'll be hoping that seeing Valdez for the third time in a month will allow their offense to get back on track. Meanwhile, they'll hope that Wheeler's Game 2 performance was an aberration as he'd posted a quality start in each of his previous four postseason appearances.

How to make Phillies vs. Astros picks

SportsLine's model is leaning Over on the total, projecting 7.7 combined runs. It also says one side of the money line has all the value. You can only get the model's World Series Game 6 pick at SportsLine. 

So who wins Astros vs. Phillies World Series Game 6? And which side of the money line has all the value? Visit SportsLine now to see which side of the Phillies vs. Astros money line to jump on, all from the advanced model that is on a 20-13 roll on top-rated MLB money-line picks, and find out.