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There are only a few weeks left in the 2025 MLB season, but you can still take advantage of the time you have remaining thanks to the bet365 promo code CBSBET365, which gives new users $300 in bonus bets instantly to use for online sports betting. All 30 MLB teams are on the Wednesday MLB schedule and a handful of the 15 games have clear playoff implications. The Cincinnati Reds are three games behind the New York Mets for the final NL Wild Card spot and they'll continue their playoff chase against the San Diego Padres at 8:40 p.m. ET tonight.

The latest MLB odds from bet365 list the Padres, who are comfortably holding onto an NL Wild Card bid, as -160 favorites with Nick Pivetta on the mound. However, the Reds will send out Andrew Abbott as their starter and are one of our MLB best bets for Wednesday at +1.5 on the run line. Before locking in your Wednesday MLB picks on your favorite betting sites like bet365, be sure to check out the rest of the top MLB betting picks from SportsLine's proven computer model. Click here to get the newest bet365 bonus code and take advantage of one of the best sportsbook promos:  

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 25 of the 2025 MLB season a profitable 34-25 on top-rated MLB money-line picks. It has excelled making home run prop picks this season, returning nearly 60 units of profit. Anybody following its MLB betting picks at sportsbooks and on betting sites could have seen strong returns.

Best Wednesday MLB picks for bet365: 

Combining the model's three picks into a Wednesday MLB parlay at bet365 would result in a payout of +749 (risk $100 to win $749). Bet it at bet365 here:

Reds +1.5 vs. Padres (-165)

This is a fantastic pitching matchup between Pivetta and Abbott, as Pivetta enters the game with a 2.85 ERA and 172 strikeouts over 164 1/3 innings while Abbott has a 2.88 ERA with 130 Ks over 142 2/3 innings. In a game that is expected to be low-scoring, playing the underdog run line is a generally smart play. This is Game 3 of the series and the Reds lost the first game 4-3 and then won the second game 4-2, so they've covered on the run line in both contests. The model has them covering in 70% of simulations. Bet it now at bet365 and get $300 in bonus bets win or lose after your first $5 wager.

Orioles (+130) to defeat the Pirates

Paul Skenes is on the mound for Pittsburgh and betting against the NL Cy Young favorite is a frightening prospect, but run support has been a problem when he's been on the mound all season. Skenes is only 10-9 despite sporting a 1.98 ERA on the season and the Pirates are 16-13 overall in his 29 starts overall. Meanwhile, the Orioles are out of postseason contention but are closing the year strong, having won six of seven games so far in September. They're also above .500 (52-49) since Tony Mansolino took the reins as managers. The model says Baltimore wins in 51% of simulations, so jump on this price from bet365 to get $300 in bonus bets after your first $5 wager.

Nationals (+130) to defeat the Marlins

We backed the Nats for plus-money yesterday and they came through with a 7-5 win. Josh Bell started the party with a three-run homer in the first inning and Mitchell Parker was solid against the Marlins yet again, giving up two earned runs over 7 2/3 innings. That was also their seventh victory in their last eight games. Today the Marlins will go with Eury Perez (4.66 ERA) while the Nationals will send out Jake Irvin (5.71 ERA). With neither pitcher throwing particularly well this season, the model is going with the hot offense, as Washington wins in 54% of simulations. Use the bet365 promo code CBSBET365 for $300 in bonus bets or a $1,000 safety net on your first wager.

Want more MLB picks for Wednesday, September 10?

You've seen the model's Wednesday MLB best bets. Now, get against the spread, total and money-line picks for Wednesday MLB games, along with the Week 2 NFL schedule and college football, all from the model that's simulated every game 10,000 times. 

Also at SportsLine:

You can also see Tuesday MLB picks from SportsLine expert Bruce Marshall, who is 140-126-3 (+2533) over his last 269 MLB picks. He's already locked in an MLB pick for Wednesday. See his best bets right here.