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The Boston Celtics will look to win their fourth game in a row when they battle the Chicago Bulls in a key Eastern Conference matchup on Monday night. Boston is coming off a 146-115 win over the Los Angeles Clippers on Saturday, while Chicago dropped a 112-99 decision to the Charlotte Hornets that same day. The Bulls (17-18), who are third in the Central Division, are 7-9 on the road this season. The Celtics (22-12), who are second in the Atlantic Division, are 10-5 on their home court in 2025-26. Chicago's leading scorer Josh Giddey (hamstring) has been ruled out. 

Tipoff from TD Garden in Boston is set for 7:30 p.m. ET. The Celtics lead the all-time series 137-110, including wins in six of the past seven meetings. Boston is a 10.5-point favorite in the latest Bulls vs. Celtics odds from SportsLine consensus, while the over/under for total points scored is 236.5. Before making any Celtics vs. Bulls picks, check out the NBA predictions and betting advice from the SportsLine Projection Model.

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The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight-plus seasons. The model enters Week 12 of the 2025-26 NBA season on a sizzling 33-15 roll on top-rated NBA spread picks dating back to last season. Anyone following its NBA betting advice at sportsbooks and on betting apps could have seen huge returns.    

Now, the model has simulated Celtics vs. Bulls 10,000 times and just revealed its coveted NBA picks and betting predictions. You can head to SportsLine now to see the model's picks. Here are several NBA odds and NBA betting lines for Bulls vs. Celtics:

Bulls vs. Celtics spread:    

Boston -10.5 at DraftKings    

Bulls vs. Celtics over/under:    

236.5 points

Bulls vs. Celtics money line:    

Boston -493, Chicago +374

Bulls vs. Celtics picks:    

See picks at SportsLine

Bulls vs. Celtics streaming:

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How to make Bulls vs. Celtics picks

SportsLine's model is going Over on the total (236.5 points). The total has gone over in four of the last seven head-to-head meetings. The Over has also hit in two of the last three Bulls games, and in three of the last five Celtics games. Both teams are 7-3 against the spread over the past 10 games. The SportsLine model is projecting Chicago's Coby White to score 20.7 points on average and be one of six Bulls players to score 12.4 or more points. Boston's Jaylen Brown, meanwhile, is projected to have 30.3 points as five Celtics players score 11.5 points or more.

It has also generated an against-the-spread pick that hits in well over 50% of simulations. You can head to SportsLine to see the model's NBA picks

So who wins Celtics vs. Bulls, and which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the Bulls vs. Celtics spread to back, all from the model that has returned well over $10,000 on top-rated NBA picks, and find out.