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The New York Giants will host the Carolina Panthers in the second week of NFL preseason games on Friday. The Carolina Panthers finished the 2022 campaign with a 7-10 record and traded up in the 2023 NFL Draft to select quarterback Bryce Young with the No. 1 pick. The Giants went 9-7-1 last season and secured a Wild Card victory over the Minnesota Vikings. Both teams dropped their Week 1 NFL preseason game.  

Kickoff is set for 7 p.m. ET. New York is a 3-point favorite in the latest Panthers vs. Giants odds, while the over/under for total points scored is 39. Before making any Panthers vs. Giants picks or predictions, you need to see what proven SportsLine NFL expert R.J. White has to say.

Over the past seven years, White, a CBS Sports fantasy and gambling editor, has gone 376-290-24 in the world's most prestigious football handicapping competition, the Las Vegas SuperContest. He also is SportsLine's No. 1 NFL expert, going 535-450-30 on his against-the-spread NFL picks from 2017-22, returning $3,532 to $100 players. Anyone who has followed him is way up.

Now, White has locked in on Panthers vs. Giants from every angle and just locked in his NFL picks and predictions. You can visit SportsLine now to see his picks. Here are several NFL odds and betting lines for Panthers vs. Giants: 

  • Panthers vs. Giants spread: Giants -3  
  • Panthers vs. Giants over/under: 39 points  
  • Panthers vs. Giants money line: New York -160, Carolina +135 
  • CAR: Panthers are 6-2 ATS in their last 8 games overall 
  • NYG: Giants are 5-1 ATS in their last 6 games overall 
  • Panthers vs. Giants picks: See picks here.

Why the Panthers can cover

Receiver Laviska Shenault Jr. brings a strong dynamic to the offense for the Panthers. Shenault Jr. is able to make defenders miss after the catch while owning the versatility to line up in multiple spots. Over three NFL seasons, he has caught 27 receptions for 1,491 yards and six touchdowns.

Tight end Tommy Tremble is another young playmaker looking to impress the coaching staff. Tremble is a solid blocker with steady hands as a pass-catcher. The Notre Dame product is listed as the No. 3 tight end on the depth chart. Tremble has snagged 39 catches with 354 yards and four touchdowns in two seasons in Carolina. Safety Jammie Robinson was selected in the fifth round of the 2023 NFL Draft. Robinson has played snaps at safety, corner, and linebacker, showcasing his skillset. The Florida State product piled up 180 solo tackles, seven interceptions, and 16 pass deflections in his college career. See which team to pick here.

Why the Giants can cover

New York added a slew of playmakers to the team this offseason. Receiver Jalin Hyatt was selected in the third round of the 2023 NFL Draft and adds juice to the offense. Hyatt has the ability to stretch the field with ease due to his superb quickness. In 2022 at Tennessee, he had 67 catches for 1,267 yards and 15 touchdowns. 

Jamison Crowder is a veteran pass-catcher looking to secure a roster spot. Crowder excels in the slot due to his sudden movements and secure hands. The Duke product has caught 415 passes for 4,667 yards and 28 touchdowns over eight NFL seasons. Additionally, quarterback Tommy DeVito will try to lock down the No. 3 spot on the depth chart. DeVito got off to a solid start, racking up 155 passing yards and one passing touchdown against the Lions. See which team to pick here.

How to make Panthers vs. Giants picks

White has analyzed this matchup and while we can tell you he's leaning Over the point total, he has also discovered a critical X-factor that has him jumping all over one side of the spread. He's only sharing what it is, and which side to back, at SportsLine.

Who wins Giants vs. Panthers, and which critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see which side of the Panthers vs. Giants spread to back, all from the expert who is on a 39-20 run on picks involving New York, and find out.