Thursday Night Football odds, spread, line: Titans vs. 49ers prediction, NFL picks from expert who's 21-10

Larry Hartstein has his finger on the pulse of Ryan Tannehill, A.J. Brown, and the Tennessee Titans

The road was not kind to the San Francisco 49ers in 2018, when they lost all eight of their games away from home. The club made a dramatic turnaround the following season, going 7-1, and is 17-6 on the road since that dismal campaign. San Francisco (8-6) will attempt to improve upon its 5-2 road record this season when it visits the AFC South-leading Tennessee Titans on Thursday Night Football.

Kickoff from Nissan Stadium in Nashville, Tenn., is scheduled for 8:20 p.m. ET. San Francisco is a three-point favorite in the latest 49ers vs. Titans odds at Caesars Sportsbook, while the over-under for total points scored is 45. Before locking in any Titans vs. 49ers picks or NFL predictions, make sure you check out what SportsLine expert Larry Hartstein has to say.

A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed while working for Pro Football Focus. Entering the 2021 campaign, Hartstein was 351-291 all-time on NFL sides, returning more than $2,200 for $100 bettors.

In addition, Hartstein is an expert on the Titans. He is a blistering 21-10-1 in his last 32 against-the-spread picks involving Tennessee, returning more than $1,000 for $100 bettors. Anyone who has followed him is way up.

Now, Hartstein has locked in on 49ers vs. Titans from every angle and released a confident against-the-spread pick. You can visit SportsLine now to see his TNF picks. Here are several NFL odds and betting lines for Titans vs. 49ers:

• Titans vs. 49ers spread: San Francisco -3
• Titans vs. 49ers over-under: 45 points 
• Titans vs. 49ers money line: San Francisco -170, Tennessee +145
• SF: 49ers are 5-1 against the spread in their last six games 
• TEN: Titans are 7-1-1 ATS in their last nine meetings with San Francisco
  

Why the 49ers can cover

After being limited to eight games last season due to injuries, George Kittle again is proving to be one of the top tight ends in the NFL in 2021. Despite having missed three contests earlier this year with a calf injury, the 28-year-old is 150 receiving yards away from reaching 1,000 for the third time in four campaigns. Kittle leads the 49ers with 63 receptions and six touchdown catches, half of which have come over his last three games.

In addition to TDs, Kittle has racked up the yards in that span, gaining 425 on 33 receptions. He fell seven yards shy of a third straight 100-yard performance in Sunday's 31-13 triumph over Atlanta, hauling in all six passes that were thrown his way. Kittle has amassed 4,429 receiving yards, the third-most by a tight end over his first five seasons in NFL history.

Why the Titans can cover

Despite having lost 2020 NFL rushing leader Derrick Henry to a fractured foot after eight games, Tennessee ranks fourth in the league in rushing with an average of 142.3 yards per contest. The Titans have outgained their opponents on the ground in their last four outings, eclipsing the 200-yard mark twice in that span. D'Onta Foreman has begun to find his groove while filling in for Henry, posting 100-yard performances in two of his last three contests.

Tennessee has been exceptional defending against the run this season, as it is second in the NFL (86.9 yards). In its last two games, the club limited Jacksonville to eight rushing yards and held Pittsburgh to 35. The Titans surrendered a total of 19 points in those contests after giving up 21 or more in each of their previous three outings.

How to make Titans vs. 49ers picks

For Thursday Night Football, Hartstein is leaning Over on the point total, but he also says a critical X-factor makes one side of the spread a must-back. He's only sharing what it is and which side of the Titans vs. 49ers spread to back at SportsLine.

So who wins 49ers vs. Titans on Thursday Night Football? And what critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see which side of the 49ers vs. Titans spread you should jump on, all from the NFL expert who's an amazing 21-10 on picks involving Tennessee, and find out.