Sigle (ankle) has been ruled out ahead of Sunday's game against the Falcons.
Sigle managed to upgrade to a limited participant in Friday's practice after missing consecutive sessions to start Week 7 prep. The strong safety's last-minute upgrade in participation level was not enough to enable him to suit up for Sunday's game, leaving Malik Mustapha as a starter in the 49ers' secondary for a third consecutive week.
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49ers' Marques Sigle: DNP Wednesday
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Sigle (ankle) did not participate in Wednesday's practice, Harrison Rich of the San Francisco Chronicle reports.
Sigle has not practiced since being diagnosed as week-to-week with the high-ankle sprain he sustained in the 49ers' Week 4 win over the Broncos. Wednesday's injury report signals that Malik Mustapha is once again taking first-team reps at strong safety in Sigle's place in anticipation of the team's Week 7 game against the Falcons.
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49ers' Marques Sigle: Deemed out for Monday Night Football
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Sigle (ankle) won't play in Monday's Week 6 matchup against Washington, Cam Inman of The San Jose Mercury News reports.
Sigle is dealing with a high-ankle sprain that he suffered Week 4 versus Denver. The second-year safety missed this past Sunday's win over Seattle and is now set to sit out a second straight game. In Sigle's absence, Malik Mustapha will likely draw another start.
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49ers' Marques Sigle: No practice Thursday
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Sigle (ankle) didn't take part in Thursday's practice, Matt Barrows of The Athletic reports.
After Sigle suffered a high-ankle sprain in Week 4, head coach Kyle Shanahan said that the second-year pro was slated to miss multiple weeks. With one absence under his belt so far and no practice reps to begin Week 6 prep, he appears to be trending toward another DNP on Monday versus the Commanders. The 49ers can confirm as much when they post their final injury report of the week Saturday.
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49ers' Marques Sigle: Dealing with ankle injury
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Sigle suffered an ankle injury during Sunday's 24-14 win over the Broncos.
Sigle finished the game having recorded six total tackles (four solo), but he picked up an ankle injury along the way. The safety's status at the team's first practice of the week Wednesday will shed more light on his availability for Week 5 against the Seahawks.
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49ers' Marques Sigle: Gets first career sack Sunday
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Sigle recorded seven tackles (three solo), including 1.0 sacks, during Sunday's 35-13 win versus the Dolphins.
Sigle followed up a strong performance in Week 1 with another good game in Week 2, and he has now logged six-plus tackles in all of his last four games going back to last postseason. He has probably played himself into IDP consideration in some formats going into a Week 3 matchup versus the Cardinals.
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49ers' Marques Sigle: Racks up nine tackles in win
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Sigle recorded nine tackles (four solo) during the 49ers' 27-7 win against the Rams in Week 1.
Sigle was on the field for all 61 of San Francisco's defensive snaps in Week 1, and his tackle total was the second best on the team behind Fred Warner's 11. He may be a worthwhile IDP consideration in some leagues heading into a Week 2 matchup versus the Giants.
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49ers' Marques Sigle: Practices Saturday
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Sigle (oblique) was a full participant in Saturday's practice, Matt Maiocco of NBC Sports Bay Area reports.
Sigle suffered an oblique injury during last Thursday's preseason contest against the Titans. The strong safety's full participation in Saturday's session implies he has moved past the issue and will be ready for next Thursday's preseason game against the Chargers. Sigle logged two tackles (one solo) against the Titans before finishing his night due to the oblique issue.
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49ers' Marques Sigle: Fills in for injured starter
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Sigle finished the 2025 regular season with 52 tackles (28 solo) and two passes defended across 15 games with the 49ers.
The fifth-round rookie began his pro career by making five starts in place of injured safety Malik Mustapha. Sigle accrued 39 of his 52 tackles during that span, showing flashes of IDP utility. The 23-year-old figures to serve as depth behind Mustapha and Ji'Ayir Brown in 2026, especially with Jason Pinnock set to become an unrestricted free agent this offseason.
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49ers' Marques Sigle: Healthy scratch Sunday
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Sigle (coach's decision) is inactive for Sunday's game against the Giants, Briana Jeannel of the 49ers' official site reports.
The safety started the first seven games of the season and played on every defensive snap from Week 1 to Week 5, but he saw his playing time drop from 62 percent of the defensive snaps to 31 percent to zero over the last three weeks, following the return of Malik Mustapha (knee) from injured reserve. Jason Pinnock is serving as San Francisco's third safety behind Mustapha and Ji'Ayir Brown.
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49ers' Marques Sigle: Logs three tackles in preseason win
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Sigle (knee) logged three tackles (three solo) in San Francisco's preseason win over the Raiders on Saturday.
Sigle had suffered a knee injury in practice earlier this month but is now healthy again. The 23-year-old was selected by the 49ers in the fifth round of this year's draft, and he is looking to earn a spot on the team's final roster as a backup safety.
San Francisco head coach Kyle Shanahan said Saturday that Sigle will still undergo testing but that initial indications are that he's avoided a serious knee injury, Nick Wagoner of ESPN.com reports.
Sigle was forced out of Saturday's 30-9 preseason loss to the Broncos early due to a knee issue, and Shanahan praised the rookie fifth-round pick's level of play prior to his departure. It remains to be seen, however, whether Sigle's injury will impact his status for the 49ers' next preseason contest on Saturday, Aug. 16 at Las Vegas.
