Lee was activated from the practice squad Wednesday, Justin Rogers of The Detroit News reports.
Lee was waived by Detroit on Nov. 20 after appearing in five games this season but was signed to the practice squad again since then. The vacancy on the active roster comes from the placement of linebacker Jalen Reeves-Maybin (neck) on injured reserve.
The Lions waived Lee on Tuesday.
Lee was signed to Detroit's active roster on Sept. 29, and he appeared in five games, totaling two tackles. The second-year defensive end accrued 3.5 sacks in his rookie season, making it likely he'll latch on with another team.
With Ziggy Ansah (shoulder) scheduled to miss his third consecutive game, the Lions decided to add some depth to the defensive line. Lee spent the end of last season in New England before being released by the team during roster cuts earlier this month. In a corresponding move, the Lions waived tackle Andrew Donnal.
Lee is officially active for Saturday's divisional-round game against the Titans despite ankle and finger injuries.
Lee was listed as questionable and was a limited practice participant throughout the week. The 23-year-old should serve his usual rotational role at defensive end for the Patriots against the Titans.
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