Preseason
| WK | Date | OPP | Result | Record |
|---|---|---|---|---|
| 1 | Aug 14, 2021 | vs | 1-0 | |
| 2 | Aug 21, 2021 | @ | 2-0 | |
| 3 | Aug 28, 2021 | @ | 3-0 |
Regular season
| Wk | Date | OPP | Time | TV | Venue | Buy Tickets |
|---|---|---|---|---|---|---|
| 2 | Sep 19, 2021 | vs |
NBC
|
M&T Bank Stadium | ||
| 3 | Sep 26, 2021 | @ | Ford Field | |||
| 4 | Oct 3, 2021 | @ | Empower Field at Mile High | |||
| 5 | Oct 11, 2021 | vs |
ESPN
|
M&T Bank Stadium | ||
| 6 | Oct 17, 2021 | vs | M&T Bank Stadium | |||
| 7 | Oct 24, 2021 | vs | M&T Bank Stadium | |||
| 9 | Nov 7, 2021 | vs |
FOX
|
M&T Bank Stadium | ||
| 10 | Nov 11, 2021 | @ |
FOX
|
Hard Rock Stadium | ||
| 11 | Nov 21, 2021 | @ | Soldier Field | |||
| 12 | Nov 28, 2021 | vs |
NBC
|
M&T Bank Stadium | ||
| 13 | Dec 5, 2021 | @ | Heinz Field | |||
| 14 | Dec 12, 2021 | @ | FirstEnergy Stadium | |||
| 15 | Dec 19, 2021 | vs |
FOX
|
M&T Bank Stadium | ||
| 16 | Dec 26, 2021 | @ | Paul Brown Stadium | |||
| 17 | Jan 2, 2022 | vs |
FOX
|
M&T Bank Stadium | ||
| 18 | Jan 9, 2022 | vs | M&T Bank Stadium |
