NCAA Tournament 2021 odds, picks, Sweet 16 predictions: This 2-way college basketball parlay would pay 13-5

Larry Hartstein is up over $3,100 on his college basketball spread picks over the past two years, and he has a two-team Sunday college basketball parlay that would return 13-5

The 2021 NCAA Tournament will be down to the Elite Eight after Sunday's four Sweet 16 games. The first game of the day features the No. 1 seed Gonzaga Bulldogs and the No. 5 seed Creighton Bluejays. The Bulldogs (28-0) can take one more step in their journey to become the first undefeated national champion since Indiana in 1976. Meanwhile, the Bluejays (22-8) are making their first Sweet 16 appearance since 1974. They had been winless in their last eight games in the round of 32. 

William Hill Sportsbook lists the Bulldogs as 13.5-point favorites in the latest Gonzaga vs. Creighton odds. Tip-off is set for 2:10 p.m. ET. The other three games on Sunday are Michigan vs. Florida State, Alabama vs. UCLA and USC vs. Oregon. Before making any 2021 NCAA Tournament picks or predictions on those games, you need to see what red-hot SportsLine expert Larry Hartstein has to say.

A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach. Over the past two seasons, he is 239-188-8 against the spread with his college basketball picks, returning $3,155 to $100 players. And he enters the second week of the NCAA Tournament on a major heater, going 16-6 with his last 22 college basketball picks (encompassing the NCAA Tournament, NIT and CBI).

On Saturday, Hartstein went a perfect 3-0 on his best bets. Anyone who followed those picks took home a massive 6-1 payout. 

Now, Hartstein has locked in two confident best bets for Sunday games in the Sweet 16 of the NCAA Tournament 2021. If you parlay his picks, you could be looking at a 13-5 payout. You can see them only at SportsLine.

Top 2021 NCAA Tournament Sweet 16 expert picks for Sunday

After breaking down each of the four Sweet 16 games on Sunday, Hartstein is leaning over 138 total points in the Oregon vs. USC matchup. This will be the second meeting between the Ducks and Trojans this season. USC defeated Oregon 72-58 on Feb. 22, combining for 130 points.

But the Trojans played that game without Isaiah Mobley, who's averaging 9.5 points per game. In addition, the Ducks uncharacteristically missed their first 12 shots of the game, en route to a 40.4 percent shooting night from the field and 55.6 percent from the line. They normally shoot 47.2 and 70.4 percent, respectively.

How to make 2021 NCAA Tournament Sweet 16 parlays for Sunday

Elsewhere on Sunday, Hartstein has found a key X-factor that has him all over a team that he says was "not overly impressive" in its last game. He's also all over another team that is "back at full strength." You can see his best bets only at SportsLine.

So which NCAA Tournament picks should you make on Sunday for a shot at a 13-5 return? And which X-factor makes one team a must-back? Visit SportsLine now to see Larry Hartstein's Sweet 16 NCAA Tournaments picks for Sunday, all from the handicapper on a massive college basketball picks run, and find out.