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The BYU Cougars take on the Arizona Wildcats at 10:30 p.m. ET on Saturday at Allegiant Stadium. The Cougars notched a 28-23 win in their most recent matchup against Arizona in September of 2018. Three years later, Arizona has yet another new head coach in Jedd Fisch following a winless 2020 campaign.

The Cougars are favored by 11.5 points in the latest Arizona vs. BYU odds from Caesars Sportsbook, and the over-under is set at 54. Before entering any BYU vs. Arizona picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of over $3,600 for $100 players on its top-rated college football picks against the spread. It also enters Week 1 of the 2021 season on a 57-37 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Arizona vs. BYU. You can head to SportsLine to see its picks. Here are several college football odds for BYU vs. Arizona:

  • Arizona vs. BYU spread: Arizona +11.5
  • Arizona vs. BYU over-under: 54 points

What you need to know about BYU 

BYU ended up 11-1 last year and capped things off with a win over the UCF Knights in the Boca Raton Bowl, and are looking to show last year wasn't a fluke. The big story for the Cougars was the play of quarterback Zach Wilson, who went on to become a first-round selection for the New York Jets in this year's NFL Draft.

Redshirt sophomore quarterback Jaren Hall is the new expected starter at the position, but he'll be leading a more inexperienced group than Wilson had in 2020. Redshirt sophomore running back Tyler Allgeier should take some of the pressure off of him after his 1,130-yard season last year. Arizona allowed 270 rushing yards per game last year, so Allgeier should be involved early and often.

What you need to know about Arizona

Fisch has been an offensive coordinator for years in both the college and professional ranks. The Wildcats are hoping that he can bring some juice back to their offense after scoring the fewest points per game in the Pac-12 last season.

Washington State transfer quarterback Gunner Cruz won the starting job, but is a relative unknown. He completed just one of his five career passes at Wazzu, and was a three-star prospect out of Casteel high school in Arizona. BYU's defensive front seven returns plenty from last year, so Cruz will likely see his share of pressure throughout. 

How to make Arizona vs. BYU picks

The model has simulated Arizona vs. BYU 10,000 times and the results are in. We can tell you that the model is leaning over, and it's also generated a point-spread pick that is hitting in almost 80 percent of simulations. You can only see the pick at SportsLine.

So who wins BYU vs. Arizona? And which side of the spread hits nearly 80 percent of the time? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.