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It hasn't been the season the Clemson Tigers (5-3) envisioned. But Dabo Swinney's squad has won three of the past four and remains mathematically alive in the ACC Atlantic Division race. The Tigers will try to pick up another win on Saturday evening when they travel to face divisional foe Louisville (4-4), a team that has lost three of its last four.

Kickoff is set for 7:30 p.m. ET at Cardinal Stadium. The Tigers are 3.5-point favorites in the latest Louisville vs. Clemson odds. The over-under for total points is set at 46.5. Before making any Clemson vs. Louisville picks, you need to see the college football predictions and betting advice from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Week 10 of the 2021 season on a 28-15 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Louisville vs. Clemson and just revealed its Week 10 college football picks and predictions. You can head to SportsLine now to see the model's CFB picks. Here are several college football odds and betting lines for Clemson vs. Louisville:

  • Clemson vs. Louisville spread: Clemson -3.5
  • Clemson vs. Louisville over-under: 46.5 points
  • Clemson vs. Louisville money line: Clemson -175, Louisville +150

What you need to know about Louisville

The Cardinals have dealt with injury issues all season, and the latest development is the loss of top cornerback Kei'Trel Clark to a torn ACL last week. But they've scrapped their way to a .500 record overall and they're a respectable 4-3 against the spread. The offense averages almost 30 points per game, and against a Clemson team that hasn't consistently put up big offensive numbers this year, Louisville has a path to covering if it can put a few touchdowns on the board.

Quarterback Malik Cunningham is the team's leading passer with 1,903 yards and rusher with 556 yards on the ground. He's been somewhat of a one-man show on offense, however, and the Cardinals will be looking for a complete team effort to pull off the upset against a talented Clemson squad. 

What you need to know about Clemson

Meanwhile, the Tigers beat the Florida State Seminoles 30-20 last Saturday. Clemson running back Will Shipley looked sharp as he rushed for two TDs and 128 yards on 25 carries. This was the first time Shipley has racked up 100+ rushing yards all year.

Clemson has been uncharacteristically mediocre in 2021. The Tigers defense remains dominant, but they have struggled to score points all year. Quarterback DJ Uiagalelei has thrown more interceptions than touchdowns in 2021, and the offense is scoring only 21.3 points per game. Clemson is 1-7 against the spread in 2021

How to make Louisville vs. Clemson picks

The model is leaning over on the point total, and it's also generated a point-spread pick that is hitting in over 60 percent of simulations. You can only see the model's Clemson vs. Louisville picks at SportsLine.

So who wins Clemson vs. Louisville? And which side of the spread hits in over 60 percent of simulations? Visit SportsLine now to see which side of the spread you need to jump on, all from the model that has crushed its college football picks, and find out.