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An ACC battle is on tap between the Syracuse Orange and the Louisville Cardinals at noon ET on Saturday at Cardinal Stadium. Louisville is 4-5 overall and 3-2 at home, while Syracuse is 5-4 overall and 2-1 on the road. Louisville has won six of the last seven meetings between these teams.

The Cardinals are favored by three points in the latest Louisville vs. Syracuse odds from Caesars Sportsbook, and the over-under is set at 55.5. Before entering any Syracuse vs. Louisville picks, you'll want to see the college football predictions from the advanced computer model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 11 of the 2021 season on a 31-20 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Louisville vs. Syracuse. You can head to SportsLine to see its picks. Here are several college football odds for Syracuse vs. Louisville:

  • Louisville vs. Syracuse spread: Louisville -3
  • Louisville vs. Syracuse over-under: 55.5 points

What you need to know about Louisville

It was all tied up 17-17 at halftime, but the Cardinals were not quite the Clemson Tigers' equal in the second half when they met on Saturday. Louisville was within a late touchdown of stealing the victory, but it took the "L" against Clemson 30-24. Louisville's loss came about despite a quality game from QB Malik Cunningham, who accumulated 174 passing yards in addition to rushing for two TDs and 134 yards. One of the most memorable plays of the game was Cunningham's 51-yard touchdown rush in the third quarter.

The entire Louisville offense hinges on Cunningham, who leads the team in both passing and rushing. He has accounted for 24 touchdowns on the year, nine via the pass and 15 on the ground. Cunningham is just the second player in ACC history to pass for 2,000 yards and rush for 15 touchdowns, joining Lamar Jackson who did it twice.

What you need to know about Syracuse

Meanwhile, while not quite a landslide, the matchup between Syracuse and the Boston College Eagles last week was still a pretty decisive one as the Orange wrapped it up with a 21-6 win at home. Running back Sean Tucker did his thing and rushed for one TD and 207 yards on 26 carries. That touchdown -- a 51-yard rush in the third quarter -- was one of the highlights of the contest.

Tucker is part of the Orange's two-headed rushing attack along with QB Garrett Shrader. The two have combined for 24 rushing touchdowns and nearly 2,000 yards on the ground. Shrader has rushed for a TD in each of his last seven games, while Tucker has scored on the ground in seven of nine contests.

How to make Syracuse vs. Louisville picks

The model has simulated Louisville vs. Syracuse 10,000 times and the results are in. We can tell you that the model is leaning under, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Syracuse vs. Louisville? And which side of the spread hits well over 50 percent of the time? Visit SportsLine now to see which side of the spread to back, all from the advanced model that has crushed its college football picks, and find out.