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The South Carolina Gamecocks have an opportunity to become bowl eligible when they face the Vanderbilt Commodores on Saturday night. South Carolina saw its four-game winning streak come to an end when it lost to Missouri at home last week. Vanderbilt has lost four straight games and is coming off its open date. South Carolina is 4-4 against the spread, while Vanderbilt is 3-5 ATS in 2022.

Kickoff is set for 7:30 p.m. ET. The Gamecocks are favored by 8 points in the latest Vanderbilt vs. South Carolina odds from Caesars Sportsbook, while the over/under is set at 49.5. Before entering any South Carolina vs. Vanderbilt picks, you'll want to see the college football predictions and betting advice from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Vanderbilt vs. South Carolina and just locked in its picks and CFB predictions. You can head to SportsLine now to see the model's picks. Here are several college football odds and betting lines for Vanderbilt vs. South Carolina:

  • Vanderbilt vs. South Carolina spread: Vanderbilt +8
  • Vanderbilt vs. South Carolina over/under: 50 points
  • Vanderbilt vs. South Carolina money line: Vanderbilt 240, South Carolina -305
  • Vanderbilt vs. South Carolina picks: See picks here

Why Vanderbilt can cover

Vanderbilt is in a nice scheduling spot on Saturday night, as it is playing at home with extra rest after having its bye week last week. The Commodores are coming off one of their best games of the season, losing to Missouri by just three points as 14-point road underdogs. They continue to be a profitable team to back within the SEC East, covering the spread in five of their last six divisional games. 

Starting quarterback AJ Swann is expected to return after sustaining an undisclosed injury against Missouri. He has thrown for more than 1,000 yards, eight touchdowns and just one interception. South Carolina quarterback Spencer Rattler has thrown a career-worst nine interceptions with just five touchdowns, which does not indicate a high probability of covering a large road spread. 

Why South Carolina can cover

South Carolina's momentum was halted against Missouri last week, but it had won four straight games prior to that setback. The Gamecocks beat multiple high-level opponents during that stretch, including then-No. 13 Kentucky and Texas A&M. Their win over Kentucky came on the road, and they also scored 30 points at then-No. 16 Arkansas in their only other road game this season. 

Vanderbilt's offense ranks last in the SEC with 341 yards per game, and an injured quarterback is not going to help that situation improve. Rattler has been dealing with some turnover issues, but the Gamecocks have a much more explosive offense than Vanderbilt, scoring at least 24 points in six of their eight games. Vanderbilt has only covered the spread twice in its last seven games and is winless in its last 13 games against South Carolina. 

How to make South Carolina vs. Vanderbilt picks

The model has simulated Vanderbilt vs. South Carolina 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You can only see the model's pick at SportsLine.

So who wins South Carolina vs. Vanderbilt? And which side of the spread hits in well over 50% of simulations? Visit SportsLine now to see which side of the Vanderbilt vs. South Carolina spread you need to jump on Saturday, all from the model that has crushed its college football picks, and find out.