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The Connecticut Huskies will take on the Vanderbilt Commodores at 7:30 p.m. ET on Saturday, October 2 at Vanderbilt Stadium. Vanderbilt is 1-3 overall and 0-3 at home, while the Huskies are 0-5 overall and 0-2 on the road. UConn is 2-3 against the spread, while Vanderbilt is 1-3 ATS in 2021.

The Commodores are favored by 14.5-points in the latest Vanderbilt vs. Connecticut odds from Caesars Sportsbook, and the over-under is set at 51. Before locking in any Connecticut vs. Vanderbilt picks, you'll want to see the college football predictions from the proven computer model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,300 for $100 players on its top-rated college football picks against the spread. After going a sizzling 9-3 in Week 4, it also enters Week 5 of the 2021 season on an 81-61 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Vanderbilt vs. Connecticut. You can head to SportsLine now to see the model's picks. Here are several college football odds and betting lines for Vanderbilt vs. Connecticut:

  • Vanderbilt vs. UConn spread: Vanderbilt -14.5
  • Vanderbilt vs. UConn over-under: 51 points
  • Vanderbilt vs. UConn money line: Vanderbilt -700, UConn +475

What you need to know about Vanderbilt

The day started off rough for Vanderbilt last Saturday, and it ended that way, too. The Commodores were dealt a punishing 62-0 loss in their SEC conference opener at the hands of the Georgia Bulldogs. Last week wasn't unusual, though, as the Commodores have made a habit of getting blown out in 2021, giving up an average of 36.8 points per game, while scoring just 12.5 points per game.

This matchup with UConn is Vanderbilt's final non-conference game of the season, and it will likely be their best chance at adding to their 2021 win total. The Commodores will likely continue to rotate between Ken Seals and Mike Wright at quarterback.

What you need to know about Connecticut

UConn fell just short of notching their first win of the 2021 season last week against Wyoming, falling by a score of 24-22. One thing holding the Huskies back has been the mediocre play of quarterback Tyler Phommachanh. Against Wyoming, Phommachanh threw for 170 yards, one touchdown, and one interception.

Like Vanderbilt, UConn has struggled mightily in 2021. The Huskies are giving up an average of 41.6 points per game and scoring only 14.2. Likewise, they are giving up 463.8 total yards per game and accumulating just 219.6 total yards of offense per contest. 

How to make Connecticut vs. Vanderbilt picks

The model has simulated Vanderbilt vs. Connecticut 10,000 times and the results are in. We can tell you that the model is leaning under on the point total, and it's also generated a point-spread pick that is hitting in over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins UConn vs. Vanderbilt? And which side of the spread hits more than 50 percent of the time? Visit SportsLine now to see which side of the spread to jump on, all from the model that has crushed its college football picks, and find out.