Brewers manager Pat Murphy said that Misiorowski will operate in a long-relief role out of the bullpen during the team's weekend series against the Reds, Jack Stern of BrewerFanatic.com reports.

Assuming he isn't needed in Friday's series opener, Misiorowski is expected to pitch multiple innings behind opener Robert Gasser in Saturday's game against Cincinnati. Misiorowski last started Sept. 19 against the Cardinals, taking a loss after yielding two runs on five hits and three walks while striking out three batters. The 23-year-old right-hander will likely remain in the bullpen for the postseason, especially if Jose Quintana (calf) is reinstated from the 15-day IL ahead of the NLDS.

Quintana (calf) threw 45 pitches in a simulated game Friday, Curt Hogg of the Milwaukee Journal Sentinel reports.

Manager Pat Murphy said he thought Quintana threw "fantastic" Friday. The left-hander is tracking toward being available for the start of the NLDS on Oct. 4. Quintana is recovering from a strained left calf and becomes eligible for reinstatement Tuesday.

Holmes will start Saturday's game against the Marlins, Laura Albanese of Newsday reports.

Holmes has been working in tandem with Sean Manaea throughout September, but both threw one inning of relief Wednesday, meaning Saturday's contest could be more of a total bullpen game. Holmes had pitched between 3.2 and 4.2 innings in his other four appearances in September.

Lodolo (groin) will throw his regularly scheduled bullpen this weekend and will not require any further evaluation, Charlie Goldsmith of Fox 19 Now Cincinnati reports.

Lodolo was lifted from Thursday's start against the Pirates with a minor groin injury, but he's a full go for his regularly scheduled bullpen and isn't concerned about the injury. If the Reds reach the postseason, Lodolo would likely be ready to make a start next week.

Atlanta optioned Waldrep to Triple-A Gwinnett on Friday, Grant McAuley of the Marietta Daily Journal reports.

Waldrep made his final start of the season Tuesday against the Nationals, so Atlanta will replace him on the roster with reliever Hayden Harris. The 23-year-old right-hander should be locked into Atlanta's 2026 rotation after collecting a 2.88 ERA, 1.19 WHIP and 55:22 K:BB in 56.1 innings this season.

Atlanta claimed Manoah off waivers from the Blue Jays on Friday and optioned him to its spring training complex.

Manoah was somewhat surprisingly designated for assignment by Toronto earlier this week and Atlanta has decided to roll the dice on the 27-year-old. The righty has been limited to just 10 rehab starts in 2025 after coming back from Tommy John surgery, and he's posted a 3.96 ERA and 35:23 K:BB across 38.2 innings. Manoah hasn't had much success at the big-league level since 2022, when he held a 2.24 ERA over 31 starts. He's under team control through 2027 and will likely compete for a spot in the Atlanta rotation next season.

McDonald is slated to start Friday's game against the Rockies in San Francisco.

The rookie right-hander will be awarded another turn through the rotation after he performed well against the Dodgers in his first MLB start this past Sunday, striking out three while allowing one earned run on six hits and one walk over six innings. McDonald will look to build on that performance with another positive outing against the Rockies, which could improve his chances of being part of the Giants' Opening Day rotation in 2026.

Horton (ribs) threw in the outfield Friday and the Cubs expect him to be ready to pitch during next week's National League Wild Card Series versus the Padres, Jesse Rogers of ESPN.com reports.

Horton underwent an MRI after exiting his last outing due to back tightness, and the imaging revealed an area of concern in his ribcage area. However, while the rookie right-hander does not appear to be 100 percent, the plan is to give him the ball against the Padres, likely in Game 1. Horton finished his first major-league season with a 2.67 ERA, 1.09 WHIP and 97:33 K:BB over 118 innings.

Sanchez is listed as the Phillies' probable starter for Sunday's regular-season finale against the Twins.

Philadelphia seemed likely to hold Sanchez out for any potential wild-card matchup, but after clinching a first-round bye in the postseason with a win Wednesday, the team has since decided to start Sanchez on Sunday in a final tuneup before Game 1 of the NLDS on Oct. 4. It could be something of an abbreviated start for Sanchez, who will not be winning the NL Cy Young over Paul Skenes but should be a finalist for the award after his first career 200-strikeout campaign.

Walker threw two scoreless innings out of the bullpen in Thursday's win over the Marlins, allowing one hit and two walks while striking out three to earn a hold.

Walker piggybacked Walker Buehler -- who started the game with five scoreless frames -- as the Phillies prepare and align their pitching staff for the postseason after clinching a first-round bye Wednesday. A longtime starter in the majors, Walker has taken well to relief work, posting a 3.32 ERA and 1.11 WHIP in 19 innings out of the bullpen this season compared to a 4.25 ERA and 1.45 WHIP as a starter.