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Watkins (ankle) is listed as doubtful for Sunday's game at Seattle, Matt Maiocco of NBC Sports Bay Area reports.

Watkins suffered a high-ankle sprain during San Francisco's preseason opener versus the Broncos, and it's now looking like there's a good chance he'll have to sit out Week 1 action as he continues to recover. The 49ers have just four healthy wide receivers going into the weekend, so there's a good chance they make a practice squad elevation prior to kickoff Sunday.

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