MLB: Milwaukee Brewers at San Francisco Giants
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Houston was without five regular members of its lineup in a 5-1 loss to Oakland on Friday night. All-Stars Jose Altuve (knee) and Yordan Alvarez (hand) joined Michael Brantley (shoulder) on the bench due to injuries, while Yuli Gurriel and Martin Maldonado were given the day off to rest. The Astros had four rookies in a lineup that was only able to muster four hits in the loss. Right-handed veteran pitcher Justin Verlander will try to get Houston back on track on Saturday afternoon.

Verlander leads the majors in wins (11) and has posted a 0.86 ERA over his last three starts. The Astros are -365 favorites (risk $365 to win $100) in the latest MLB odds at Caesars Sportsbook, while the Athletics are +285 underdogs. Who should you back in that game, and which other MLB best bets should be all over? Before making any MLB picks or parlays, be sure to check out the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it is 275-236 on top-rated MLB money-line picks since the start of the 2021 season, returning over $400 for $100 players. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen profitable returns. 

Now, the model has locked in four confident MLB best bets for Saturday. They all involve games at 4:05 p.m. ET or later, so there's still time to get these MLB picks in. If you successfully parlay the picks, you'd be looking at a payout of more than 11-1. You can see the model's MLB picks for Saturday only at SportsLine. 

Top MLB picks today

After simulating every game 10,000 times, one pick the model likes for Saturday is San Francisco to beat Milwaukee at 7:15 p.m. ET as a -130 favorite. The Brewers finally had a chance to string a few wins together on Friday night, but usually-reliable closer Josh Hader gave up six runs in the bottom of the ninth inning, as Mike Yastrzemski hit a walk-off grand slam to cap off the comeback. Milwaukee has now lost six of its last nine games and is scuffling heading into the All-Star break.

San Francisco has a great opportunity to build on its emotional win, as the Giants have now won five of their last seven games. They have gone 17-10 against left-handed starting pitchers this season-southpaw Eric Lauer will be on the mound for Milwaukee. San Francisco has a 36-29 record as a favorite this season, and SportsLine's model expects the Giants to add another win to that tally on Saturday night. 

How to make MLB picks and parlays for Saturday

The model also locked in three other best bets for Saturday, including an underdog selection. You can only see the model's MLB parlay picks and best bets for Saturday at SportsLine. 

What MLB picks should you target for a payout of more than 11-1? And which underdog is the model backing on Saturday? Visit SportsLine now to see the MLB best bets for Saturday from a model that has a 275-236 record on top-rated picks since the start of the 2021 season and find out.