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The Denver Broncos will be attempting to secure the No. 1 seed in the AFC when they host the Los Angeles Chargers in Week 18 of the 2025 NFL season. The Chargers don't have much to play for beyond seeding in the playoffs, and they're planning on resting Justin Herbert and other key starters as a result. If Denver wins this game, the Broncos will secure the top seed and get a bye in the first round of the playoffs.

Kickoff from Empower Stadium at Mile High is set for 4:25 p.m. ET on CBS and Paramount+. The Broncos are 14-point favorites in the latest Chargers vs. Broncos odds at DraftKings, and the over/under for total points scored is 37.5. Denver's over/under for total points scored is 26.5, while Los Angeles' is 10.5. Before making any Broncos vs. Chargers picks of your own, make sure to look at the top NFL picks from the SportsLine Projection Model, which simulates every NFL game 10,000 times.

Where to watch Chargers vs. Broncos on Sunday

When: Sunday, Jan. 4
Time: 4:25 p.m. ET
TV: CBS
Stream: Paramount+  
Follow along: CBS Sports App

Chargers vs. Broncos betting preview

Odds: Broncos -14, over/under 37.5

Despite its stellar record, Denver is only 6-9-1 against the spread. Los Angeles is 8-7-1 ATS but had four straight covers before losing to the Texans at home in Week 17. The Chargers are 6-9-1 to the Over while the Broncos are 7-9 to the Over.

Chargers vs. Broncos SGP

  • Chargers +14
  • Over 37.5
  • RJ Harvey anytime touchdown scorer

Bet it at DraftKings:

Model's Chargers vs. Broncos score prediction, picks

The Chargers cover the spread in 58% of model simulations and win in 27%, bringing value as +575 underdogs. The Over hits in 51% of simulations.

Chargers vs. Broncos score prediction: Broncos 25, Chargers 15

Want more Week 18 NFL picks?

You've seen the model's best bets for Los Angeles Chargers vs. Denver Broncos. Now, get against the spread, total and money-line picks for every Week 18 NFL game here, all from the model that's simulated every game 10,000 times.