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For as dominant as the Indianapolis Colts have been in the AFC South, their Achilles heel has been winning games at Jacksonville, where they are 0-7 since 2015. Indy's loss there in the season-finale last year cost the Colts a trip to the playoffs, but they have a chance for revenge when they play at Jacksonville on Sunday on Paramount+. No AFC South team won its season-opener last week after the Colts settled for a tie against Houston, so both sides will be eager to pick up their first win of 2022. You can see what happens when you stream the game in select markets on Paramount+.

Kickoff from TIAA Bank Field is set for 1 p.m. ET. Indianapolis is favored by three points in the latest Jaguars vs. Colts odds from Caesars Sportsbook, and the over/under is set at 45. In select markets, Sunday's matchup can be seen live on CBS and streamed live on Paramount+ with their must-have Premium plan.

Paramount+ now has levels of membership so you can watch your local NFL on CBS matchups and much more. The Premium Plan is $9.99 per month and you can watch your local CBS live stream, including plenty of sports like SEC on CBS, NFL on CBS, and the PGA Tour, with no ads, on demand and the ability to download episodes for offline viewing. Both plans come with a free week to start and include the NFL on CBS, so sign up now here.

How to watch Colts vs. Jaguars

  • Colts vs. Jaguars date: Sunday, Sept. 18
  • Colts vs. Jaguars time: 1 p.m. ET
  • Colts vs. Jaguars TV: CBS
  • Colts vs. Jaguars streaming: Paramount+

Week 2 picks for Jaguars vs. Colts

Before tuning into Sunday's Colts vs. Jaguars game, you need to see the NFL picks from SportsLine's advanced computer model. The model, which simulates every NFL game 10,000 times, is up more than $7,500 for $100 players on top-rated NFL picks since its inception. The model enters Week 2 of the 2022 NFL season on an incredible 139-98 run on top-rated NFL picks that dates back to the 2017 season. The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

For Colts vs. Jaguars, the model is backing the Colts to win and cover the three-point spread on the road. Indianapolis quarterback Matt Ryan has a career 68.15 completion percentage with a 4-0 record against the Jaguars. In Week 1, only five of Ryan's 50 total passes were judged to be poor throws, and he finished with the third-most air yards among all passers with an even 200. With Colts receiver Michael Pittman (quad) sidelined, the Jags could expect an even larger than normal dose of running back Jonathan Taylor, who has 446 total rushing yards and three touchdowns in his last three games against Jacksonville.

The model predicts Taylor will hit the century mark with a strong chance to score a touchdown. Indianapolis should avenge last season's finish with just a narrow victory, but one that is good enough to cover the spread on Sunday. You may be able to stream the game here.

How to watch, live stream the NFL on CBS

Now that you know what to pick, get ready to watch your live local NFL on CBS games on Paramount+ on any device you want. Visit Paramount+ now to stream your live local CBS sporting events, including the NFL, SEC on CBS, and so much more.