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The 2026 NFL Wild Card Weekend schedule features two games on Saturday, three on Sunday and one 'Monday Night Football' matchup between the Houston Texans and Pittsburgh Steelers. Monday's matchup will pit quarterback C.J. Stroud and the Houston Texans against 21-year veteran Aaron Rodgers and the Pittsburgh Steelers. The Texans are favored by 3 points at DraftKings Sportsbook.

Sunday's other largest spreads include Rams (-10.5) vs. Panthers, 49ers vs. Eagles (-4.5) and Chargers vs. Patriots (-3.5). The smallest spreads in Wild Card Weekend include Packers (-1.5) vs. Bears and Bills (-1.5) vs. Jaguars. The top seeds, Seattle in the NFC, and Denver, in the AFC, have the week off.

Before making any 2026 Wild Card Weekend NFL picks or NFL score predictions on those games or others, you need to see the NFL against the spread, over/under and money line predictions powered by the self-learning SportsLine AI.

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team's historical data and then quantitatively evaluating the strength of the opponent's defense by assigning a numeric value out of 100 called a matchup score. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. SportsLine's AI PickBot has hit more than 2,000 4.5- and 5-star prop picks since the start of the 2023 season. 

For Wild Card Weekend NFL betting, SportsLine AI has evaluated the NFL odds and provided NFL betting picks for all six games. You can only see the AI predictions for the 2026 Wild Card Weekend NFL schedule here.

Top 2026 Wild Card Weekend NFL AI picks

After analyzing every game in Wild Card Weekend, the AI says the Steelers (+3, 39.5), who outlasted Baltimore in Week 18 to win the AFC North, cover in a tight loss. 

The Texans have gone over in three of their last four games, while the over has hit in four of the last five Steelers games. Bet the Over 39.5 in the latest DraftKings promo code, which offers $300 in bonus bets if your first bet wins:

Pittsburgh has won four of the last six meetings with Houston and is expected to cover in a close game. The Steelers, who will get receiver DK Metcalf back from suspension, are looking to win their first playoff game since reaching the AFC Championship Game in 2016. Houston won the last meeting, 30-6, on Oct. 1, 2023. SportsLine AI rates the Steelers as a B money line pick and also predicts a 22-21 Texans win on average. See its other 2026 Wild Card Weekend football predictions and football picks at SportsLine, and bet the Steelers at DraftKings here:

How to make 2026 Wild Card Weekend NFL picks

In addition, the AI PickBot has generated three highly-coveted A picks for 2026 Wild Card Weekend. You need to see the AI's NFL picks before making any 2026 Wild Card Weekend NFL bets of your own. You can only see them at SportsLine.

Who wins and covers each 2026 Wild Card Weekend NFL game, and which A+ picks should you target now? Visit SportsLine now to see the top NFL picks against the spread, over-under and on the money line, all from the SportsLine AI that has nailed more than 2,000 highly-rated picks since the start of the 2023 season.