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The Seattle Seahawks will take on the Indianapolis Colts at 1 p.m. ET on Sunday at Lucas Oil Stadium. The Seahawks went 12-4 last season and won the NFC West, but lost in the first round of the playoffs to the Rams. The Colts finished with an 11-5 record and lost in the first round of the AFC playoffs to the Bills. 

Seattle is favored by three points in the latest Colts vs. Seahawks odds from Caesars Sportsbook, and the over-under is set at 49. Before entering any Seahawks vs. Colts picks, you'll want to see the NFL predictions from the model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters the 2021 season on an incredible 120-78 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the Top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP..

Now, the model has set its sights on Colts vs. Seahawks. You can head to SportsLine to see its picks. Here are several NFL betting lines for Seahawks vs. Colts:

  • Colts vs. Seahawks spread: Colts +3
  • Colts vs. Seahawks over-under: 49 points

What you need to know about the Seahawks

After losing in the NFC wild card round to the Rams, the Seahawks parted ways with offensive coordinator Brian Schottenheimer and replaced him with former Rams passing game coordinator Shane Waldron. Seattle has posted winning records in nine consecutive seasons, all with Russell Wilson at quarterback. He passed for a career-best 40 touchdowns in 2020. 

DK Metcalf set a new franchise record with 1,303 receiving yards in 2020 and caught 10 TD passes. Tyler Lockett set a team record with 100 catches and also had 10 TD receptions. Safety Jamal Adams had 9.5 sacks, the most by a defensive back in a single season since 1982.

What you need to know about the Colts

After being acquired from the Philadelphia Eagles in the offseason, Carson Wentz will make his Colts debut. It was uncertain if Wentz would be ready for the season opener after undergoing foot surgery in early August, but he will start against Seattle. He will be without veteran WR T.Y. Hilton (neck), who is on injured reserve. 

Running back Jonathan Taylor led all rookies in scrimmage yards (1,468) and rushing yards (1,169) and tied for the lead in rushing TDs (11) in 2020. He rushed for 560 yards (140 per game) and seven TDs in the last four games of 2020. Indianapolis' was second best in rushing yards allowed per game, finishing the 2020 season giving up only 90.5 on average.

How to make Colts vs. Seahawks picks

The model has simulated Colts vs. Seahawks 10,000 times and the results are in. The model is leaning under on the total, and it's also generated a point-spread pick that is hitting in over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Colts vs. Seahawks? And which side of the spread hits more than 50 percent of the time? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks.