Regular season
| Wk | Date | OPP | Time | TV | Venue | Buy Tickets |
|---|---|---|---|---|---|---|
| 1 | Sep 12, 2021 | vs |
FOX
|
Paul Brown Stadium | — | |
| 2 | Sep 19, 2021 | @ |
FOX
|
Soldier Field | — | |
| 3 | Sep 26, 2021 | @ | Heinz Field | — | ||
| 4 | Sep 30, 2021 | vs |
NFLN
|
Paul Brown Stadium | — | |
| 5 | Oct 10, 2021 | vs |
FOX
|
Paul Brown Stadium | — | |
| 6 | Oct 17, 2021 | @ |
FOX
|
Ford Field | — | |
| 7 | Oct 24, 2021 | @ | M&T Bank Stadium | — | ||
| 8 | Oct 31, 2021 | @ | MetLife Stadium | — | ||
| 9 | Nov 7, 2021 | vs | Paul Brown Stadium | — | ||
| 11 | Nov 21, 2021 | @ | Allegiant Stadium | — | ||
| 12 | Nov 28, 2021 | vs | Paul Brown Stadium | — | ||
| 13 | Dec 5, 2021 | vs |
FOX
|
Paul Brown Stadium | — | |
| 14 | Dec 12, 2021 | vs | Paul Brown Stadium | — | ||
| 15 | Dec 19, 2021 | @ | Empower Field at Mile High | — | ||
| 16 | Dec 26, 2021 | vs | Paul Brown Stadium | — | ||
| 17 | Jan 2, 2022 | vs | Paul Brown Stadium | — | ||
| 18 | Jan 9, 2022 | @ | FirstEnergy Stadium | — |
| Wk | Date | OPP | Result | Record |
|---|---|---|---|---|
| 10 | May 17, 2021 |
BYE
|
— | — |