Preseason
| WK | Date | OPP | Time | TV | Venue | Buy Tickets |
|---|---|---|---|---|---|---|
| 1 | Aug 15, 2021 | vs |
NFLN
|
Lucas Oil Stadium | ||
| 2 | Aug 21, 2021 | @ | — | U.S. Bank Stadium | ||
| 3 | Aug 27, 2021 | @ | — | Ford Field |
Regular season
| Wk | Date | OPP | Time | TV | Venue | Buy Tickets |
|---|---|---|---|---|---|---|
| 1 | Sep 12, 2021 | vs |
FOX
|
Lucas Oil Stadium | ||
| 2 | Sep 19, 2021 | vs |
FOX
|
Lucas Oil Stadium | ||
| 3 | Sep 26, 2021 | @ | Nissan Stadium | |||
| 4 | Oct 3, 2021 | @ | Hard Rock Stadium | |||
| 5 | Oct 11, 2021 | @ |
ESPN
|
M&T Bank Stadium | ||
| 6 | Oct 17, 2021 | vs | Lucas Oil Stadium | |||
| 7 | Oct 24, 2021 | @ |
NBC
|
Levi's Stadium | ||
| 8 | Oct 31, 2021 | vs | Lucas Oil Stadium | |||
| 9 | Nov 4, 2021 | vs |
FOX
|
Lucas Oil Stadium | ||
| 10 | Nov 14, 2021 | vs | Lucas Oil Stadium | |||
| 11 | Nov 21, 2021 | @ | Highmark Stadium | |||
| 12 | Nov 28, 2021 | vs |
FOX
|
Lucas Oil Stadium | ||
| 13 | Dec 5, 2021 | @ | NRG Stadium | |||
| 15 | Dec 19, 2021 | vs | — | Lucas Oil Stadium | ||
| 16 | Dec 25, 2021 | @ |
NFLN
|
State Farm Stadium | ||
| 17 | Jan 2, 2022 | vs | Lucas Oil Stadium | |||
| 18 | Jan 9, 2022 | @ | TIAA Bank Field |
| Wk | Date | OPP | Result | Record |
|---|---|---|---|---|
| 14 | — |
BYE
|
— | — |