Offensive Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Quarterback | P. Rivers Philip Rivers | J. Brissett Jacoby Brissett | |
| Running Back | J. Taylor Jonathan Taylor | N. Hines Nyheim Hines | |
| Wide Receiver | T. Hilton T.Y. Hilton | M. Pittman Michael Pittman | |
| Tight End | J. Doyle Jack Doyle | T. Burton Trey Burton | |
| Left Tackle | C. Green Chaz Green | — | — |
| Left Guard | Q. Nelson Quenton Nelson | D. Pinter Danny Pinter | — |
| Center | R. Kelly Ryan Kelly | J. Hunt Joey Hunt | — |
| Right Guard | M. Glowinski Mark Glowinski | — | — |
| Right Tackle | B. Smith Braden Smith | — | — |
Defensive Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Left Defensive End | J. Houston Justin Houston | B. Banogu Ben Banogu | |
| Right Defensive End | D. Autry Denico Autry | A. Muhammad Al-Quadin Muhammad | — |
| Left Defensive Tackle | D. Buckner DeForest Buckner | T. Lewis Tyquan Lewis | |
| Right Defensive Tackle | G. Stewart Grover Stewart | T. Stallworth Taylor Stallworth | |
| Strongside Linebacker | B. Okereke Bobby Okereke | E. Speed E.J. Speed | — |
| Middle Linebacker | A. Walker Anthony Walker | Z. Franklin Zaire Franklin | |
| Weakside Linebacker | D. Leonard Darius Leonard | M. Adams Matthew Adams | — |
| Right Cornerback | X. Rhodes Xavier Rhodes | T. Carrie T.J. Carrie | |
| Left Cornerback | R. Ya-Sin Rock Ya-Sin | K. Moore Kenny Moore | |
| Strong Safety | K. Willis Khari Willis | T. Wilson Tavon Wilson | — |
| Free Safety | J. Blackmon Julian Blackmon | G. Odum George Odum |
Special Teams Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Punter | R. Sanchez Rigoberto Sanchez | A. Rehkow Austin Rehkow | — |
| Kicker | R. Blankenship Rodrigo Blankenship | — | — |
| Long Snapper | L. Rhodes Luke Rhodes | — | — |
| Holder | R. Sanchez Rigoberto Sanchez | — | — |
| Punt Returner | N. Hines Nyheim Hines | I. Rodgers Isaiah Rodgers | — |
| Kick Returner | I. Rodgers Isaiah Rodgers | — | — |