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The Florida Gators host the South Florida Bulls at 7:30 p.m. ET on Saturday at Florida Field at Ben Hill Griffin Stadium. Both of Florida's games this season have come at home, where the Gators are 1-1, but they struggled in a loss to Kentucky last weekend. Meanwhile, South Florida is 1-1 overall and playing in their first road game of the season. The Bulls rebounded from a loss against a strong BYU team with a blowout win over Howard last Saturday. The two programs have only played each other twice, but Florida won both, with the most recent victory coming last year, 42-20.

The Gators are favored by 24.5 points in the latest Florida vs. South Florida odds from Caesars Sportsbook, and the over/under is set at 59. Before entering any South Florida vs. Florida picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,400 for $100 players on its top-rated college football picks against the spread. It enters Week 3 of the 2022 college football season on a 50-41 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Florida vs. South Florida and just locked in its CFB picks and predictions. You can head to SportsLine now to see the model's picks. Here are several college football odds for Florida vs. South Florida:

  • Florida vs. South Florida spread: Florida -24.5
  • Florida vs. South Florida over/under: 59 points
  • Florida vs. South Florida picks: See picks here

What you need to know about Florida

Florida came up short against the Kentucky Wildcats on Saturday, falling 26-16. After a breakout performance against Utah in Week 1, QB Anthony Richardson struggled in Week 2. He could only muster four yards on six carries and finished throwing for just 4.09 yards per passing attempt.

Richardson couldn't find open players for most of the night against Kentucky, and completed just 40 percent of his passes with no touchdowns and two interceptions. Running back Trevor Etienne (9 carries, 46 yards, TD) and Xzavier Henderson (6 catches, 50 yards) were the lone bright spots for the Gators on offense in the loss. Through two games, the Gators have one of the worst opponent third down conversion rates in college football, at 46.15 percent. 

What you need to know about South Florida

The Bulls made easy work of the Howard Bison on Saturday and carried off a 42-20 win. RB Brian Battie was the offensive standout of the matchup for South Florida, with one TD and 105 yards on seven carries. That touchdown, a 60-yard rush in the fourth quarter, was one of the highlights of the game.

Overall, things have been rough through Jeff Scott's first couple years as head coach, and he picked up just his fourth win in two-plus seasons last week against Howard. As badly as the Gators have struggled at getting opposing offenses off the field on third downs, USF has been even worse, and has allowed opponents to convert 53.33 percent of their third down attempts. Richardson should have much more success running the ball this week, as USF has allowed 6.26 yards per attempt on opponent rushes.

How to make Florida vs. South Florida picks

The model has simulated Florida vs. South Florida 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it's also generated a point-spread pick that is hitting in nearly 60% of simulations. You can only see the model's pick at SportsLine.

Who wins Florida vs. South Florida? And which side of the spread is a must-back? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks and find out.