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An ACC battle is on tap between the Duke Blue Devils and the North Carolina Tar Heels at noon ET on Saturday at Kenan Memorial Stadium. UNC is 2-2 overall and 2-0 at home, while Duke is 3-1 overall and 0-1 on the road. The Tar Heels have dominated this rivalry in recent years, winning 12 of their last 17 matchups against the Blue Devils.

UNC is favored by 20 points in the latest North Carolina vs. Duke odds from Caesars Sportsbook, and the over-under is set at 72.5. Before entering any Duke vs. North Carolina picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,300 for $100 players on its top-rated college football picks against the spread. After going a sizzling 9-3 in Week 4, it also enters Week 5 of the 2021 season on an 81-61 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on North Carolina vs. Duke. You can head to SportsLine to see its picks. Here are several college football odds for North Carolina vs. Duke:

  • North Carolina vs. Duke spread: UNC -20
  • North Carolina vs. Duke over-under: 72.5 points

What you need to know about North Carolina

The Tar Heels scored first but ultimately less than the Georgia Tech Yellow Jackets in their game last Saturday. UNC has to be aching after a bruising 45-22 defeat to Georgia Tech. No one had a standout game offensively for UNC, but the Tar Heels got scores from WR Josh Downs and TE Kamari Morales.

Despite suffering a setback in their last outing, the Tar Heels will enter Saturday's showdown confident they can secure a big win. That's because North Carolina is 9-1 in its last 10 games at home. The Tar Heels also dominated the Blue Devils last season, beating Duke 56-24 as 11.5-point favorites. 

What you need to know about Duke

Meanwhile, the Blue Devils strolled past the Kansas Jayhawks with points to spare last Saturday, taking the contest 52-33. Running back Mataeo Durant had a big day for the Blue Devils, rushing 21 times for 124 yards and a touchdown. Quarterback Gunnar Holmberg also had a strong showing, throwing for 328 yards and one touchdown. Holmberg also carried the ball 17 times for 88 yards and four scores against the Jayhawks.

Durant ranks third in the nation in rushing, having already racked up 522 rushing yards this season. He leads a Duke offense that's averaging 38.8 points per game, which ranks 20th in the nation. 

How to make Duke vs. North Carolina picks

The model has simulated UNC vs. Duke 10,000 times and the results are in. We can tell you that the model is leaning over, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins UNC vs. Duke? And which side of the spread is a must-back? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks, and find out.