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Winning in their own building has been almost automatic of late for the UCF Knights, who have lost only two of their 33 home games since 2017. Since FBC Mortgage Stadium opened in 2007, UCF has posted a .771 winning percentage (74-22) there, which ranks among the 15 best in the nation in a current home stadium. The Knights attempt to improve that mark when they host the Louisville Cardinals on Friday. UCF (1-0) continued its home success with a 56-10 triumph over South Carolina State in its 2022 season opener, while Louisville (0-1) began the year with a 31-7 loss at Syracuse. The Cardinals have won two of their three all-time meetings with the Knights.

Kickoff at FBC Mortgage Stadium in Orlando, Fla. is set for 7:30 p.m. ET. The Knights are 5.5-point favorites in the latest UCF vs. Louisville odds from Caesars Sportsbook, while the over/under for total points scored is 61.5. Before making any Louisville vs. UCF picks, you need to see the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,500 for $100 players on its top-rated college football picks against the spread. It enters Week 2 of the 2022 college football season on a 48-37 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on UCF vs. Louisville and just revealed its picks and CFB predictions. You can visit SportsLine now to see the model's picks. Here are several college football odds and betting lines for Louisville vs. UCF: 

  • UCF vs. Louisville spread: Knights -6 
  • UCF vs. Louisville over/under: 61.5 points 
  • UCF vs. Louisville money line: Knights -225, Cardinals +185
  • UCF: The Knights are 1-6 against the spread in their last seven games following an ATS win 
  • LOU: The Cardinals are 6-1 ATS in their last seven contests after scoring fewer than 20 points in their previous game 
  • UCF vs. Louisville picks: See picks here.

Why UCF can cover

The Knights are well on their way to posting another incredible point total over their first two contests of the season. UCF has recorded at least 94 combined points in its opening pair of games every year since 2017 and needs 44 on Friday to reach triple digits for the third time during the stretch. The club scored eight touchdowns in its 2022 opener, with seven coming from an offense that racked up 600 total yards.

Five of those seven TDs were produced by new quarterback John Rhys Plumlee, who threw for four and ran for another in his UCF debut. A transfer from Ole Miss when spent last season as a wide receiver, Plumlee completed 20-of-31 pass attempts for 308 yards and gained a team-high 86 yards on the ground. UCF's special teams also came up big against South Carolina State as junior safety Quadric Bullard recorded the team's first blocked punt since 2019 and recovered the ball in the end zone for a touchdown.

Why Louisville can cover

The Cardinals will need a performance similar to the one they had in the matchup last year, when they outgained the Knights 501-416 in total offense. Quarterback Malik Cunningham was a dual threat in Louisville's victory, throwing for 265 yards and a touchdown while running for 99 yards and a pair of scores. The senior signal-caller, who had multiple rushing TDs in eight of his 12 regular-season games in 2021, hopes to rebound from last week's loss in which he had his streak of consecutive contests with at least one passing or rushing touchdown halted at 30.

One of Louisville's lone bright spots in the setback at Syracuse was its ground game, which was led by newcomer Tiyon Evans. The transfer from Tennessee gained 89 yards on 13 carries in his team debut, with 36 coming on his first-quarter TD run. Fellow junior Tyler Hudson, a wideout who spent the previous three years at Central Arkansas, also impressed as he made eight catches for 102 yards to become the fourth player in school history to reach triple digits in receiving yards in his first game with the Cardinals.

How to make UCF vs. Louisville picks

SportsLine's model is leaning Over on the point total. In fact, it says the starting quarterbacks combine for more than five total touchdowns. It also has generated an against-the-spread pick that cashes in almost 70% of simulations. You can only see the model's Louisville vs. UCF pick at SportsLine.

So who wins UCF vs. Louisville? And which side of the spread hits almost 70% of the time? Visit SportsLine now to see which side of the Louisville vs. UCF spread to back, all from the advanced model that is up almost $3,500 on its top-rated college football spread picks, and find out.