Jon Jones is the latest UFC main event star to be a late scratch from a pay-per-view. This time, it just so happens to be the biggest pay-per-view in the company's history.

The light heavyweight interim titleholder has been pulled from the UFC 200 mega card this Saturday in Las Vegas after being informed of a potential doping violation by the USADA.

Brock Lesnar's surprising return to the Octagon one year after announcing his retirement now slides into the main event role as he will take on Mark Hunt in the final match of the card.

Jones will have the opportunity for a full appeal process, but he will not face Daniel Cormier for the unified light heavyweight title belt on Saturday. If Jones' failed drug test were to stand, UFC president Dana White, who spoke with the media on Wednesday night, said that Jones could face up to a two-year ban.

White, who was clearly blindsided and upset by the news while speaking at the emergency press conference, expressed what most every fight fan was feeling after hearing the news.

"This sucks," said White. "I don't know what to say. It sucks. It's unfortunate."

White also noted that Cormier was "devastated" by the news and Cormier spoke with reporters briefly on Wednesday night after finding out he was without an opponent for Saturday, noting his frustration and disappointment.

"More than anything just really disappointed," said Cormier.

While there is still potential for a last-minute replacement to face Cormier, White said he would only schedule that match if they could make a good fight. If they can't find a worthy opponent that they feel will make a good fight -- which will be extremely difficult with two days notice -- White said he'd rather not have Cormier fight at all, noting the strength of the total card.

Cormier also noted that he was more than willing to fight a different opponent on Saturday night and was even willing to consider taking on a fighter at 220 or 225 pound. There will be plenty of fighters chomping at the bit to get a title shot on the UFC 200 card, and White said on Thursday that Cormier would get a new opponent for Saturday night.

UFC released an official statement on the matter on Wednesday night:

The UFC organization was notified tonight that the U.S. Anti-Doping Agency (USADA) has informed Jon Jones of a potential Anti-Doping Policy violation stemming from an out-of-competition sample collection on June 16, 2016. USADA, the independent administrator of the UFC Anti-Doping Policy, will handle the results management and appropriate adjudication of this case. It is important to note that, under the UFC Anti-Doping Policy, there is a full fair legal review process that is afforded to all athletes before any sanctions are imposed. However, because Jones was scheduled to compete against Daniel Cormier this coming Saturday, July 9 in Las Vegas, there is insufficient time for a full review before the scheduled bout and therefore the fight has been removed from the fight card.

Here are three things to know about Jones being pulled from the UFC 200 card:

1. This is an extremely bad look for Jon Jones. This is a guy who has spoken in the buildup for this fight and his UFC 197 fight about redemption and changing his path. During Wednesday's press conference, Jones said this to reporters about UFC 200 being a chance to get back on track with his life.

"I've had a long, long year," said Jones. "A really long year with court cases and lawsuits, just a whole bunch of stuff. Forget about it, right? I think a big part of me forgetting about it and being able to move forward in my life is redeeming myself completely and doing the right things in the future. But getting this belt back is a huge part of that. That's what I'm going to do."

Less than 10 hours after saying that, Jones gets informed of a possible anti-doping violation and gets yanked off of the biggest event in UFC history -- or at least that was the goal of the 200 card. Winning the appeal will be crucial for Jones, who not only needs to avoid a 2-year ban from the sport, but a failed drug test could have ramifications for his probation. When asked about how this would affect Jones' probation for his hit-and-run last year, White said, "it can't be good."

It's sad to see a talent as incredibly gifted as Jones continue to struggle with issues outside of the ring. Jones' rise to the top of the sport was meteoric and his fall has been equally startling. He's said all of the right things in the build up about moving on from his stint in rehab for cocaine use in January 2015 and his hit-and-run incident in April 2015 that led to a year-long suspension, but it seems that he's not able to heed his own advice when it comes to avoiding trouble.

And just like that, UFC 200 has been thrown into a blender. Getty Images

2. The timing of the failed test could not be worse for all parties involved. Take away the fact that there's never a good time for a failed drug test by a main event fighter and you'll notice that the timing could not be worse for everyone. For Jones, on top of it being a terrible look for a star that has become more known for his out-of-the-ring issues than his skills in it, he can't push his appeal through in time to have a decision made prior to the event's start.

For Cormier, he's put in the predicament of really wanting to fight this Saturday, but would be picking a potential opponent -- which he says he's willing to go all the way up to 225 for -- on two days notice. That's not an ideal situation for a champion and is, really, quite unfair.

Finally, for UFC, it's a disaster. After pulling McGregor-Diaz 2 and standing firm in not letting him back on the 200 card after their spat over the promotional tour, the 200 card came together well. Now, they lose another main event -- more on that in a moment -- and have to deal with the immediate business fallout and the possibility of one of the sports biggest stars catching a two-year ban.

In the company's statement, UFC announced that ticket refunds would be made available at the primary point of purchase for fans. There could be a significant loss of revenue, both from in-arena ticket refunds and loss of pay-per-view buys, from this happening so close to the fight.

3. This is the 22nd change to a main event or co-main event on a UFC card in 2016. This has been a nightmare year for UFC main events. According to Mike Bohn of MMA Junkie, this will be the 22nd change to a main event or co-main event this year and the second time the UFC 200 main event has been changed -- the first being Conor McGregor-Nate Diaz being pulled. That is an insane number of card changes to barely be into July.