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The Denver Broncos will take on the New York Giants at 4:25 p.m. ET on Sunday at MetLife Stadium. The Giants started out 0-5 last season and finished at 6-10. The Broncos finished 5-11, losing five of their last six games.

Denver is favored by three points in the latest Giants vs. Broncos odds from Caesars Sportsbook, and the over-under is set at 41.5. Before entering any Broncos vs. Giants picks, you'll want to see the NFL predictions from the model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters the 2021 season on an incredible 120-78 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the Top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Giants vs. Broncos. You can head to SportsLine to see its picks. Here are several NFL betting lines for Broncos vs. Giants:

  • Giants vs. Broncos spread: Giants +3
  • Giants vs. Broncos over-under: 41.5 points

What you need to know about the Giants

The Giants missed the playoffs for the fourth consecutive season in 2020. In the first year of the post-Eli Manning era, New York ranked second worst in the NFL in passing touchdowns with only 12. Daniel Jones ranked 30th in the league in quarterback rating at 80.4. He was second on the team in rushing with 423 yards. 

Saquon Barkley is listed as questionable for Week 1, as h has been recovering from a torn ACL. Evan Engram (calf) is out for the season opener. New acquisition Kenny Golladay dealt with a hamstring injury in the preseason, but is not listed on the injury report.  

What you need to know about the Broncos

Denver will try to avoid a fifth consecutive losing season in 2021. The Broncos traded for quarterback Teddy Bridgewater in the offseason and he beat out Drew Lock for the starting job in the preseason. He set career highs in passing yards (3,733) and TD passes (15) last year with the Panthers. Second-year WR Jerry Jeudy should be one of his top targets this season. 

Courtland Sutton, who has been recovering from a torn ACL, will be ready for the season opener. Von Miller is also ready to return after recovering from an ankle injury that ended his 2020 season in September. Bradley Chubb (ankle) is questionable for Sunday's game. 

How to make Broncos vs. Giants picks

The model has simulated Giants vs. Broncos 10,000 times and the results are in. It is leaning over on the total, and it also says one side of the spread has all the value. You can only see the pick at SportsLine.

So who wins Broncos vs. Giants? And which side of the spread has all the value? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks.