Your Week 6 NFL office pool picks will include a choice for Vikings vs. Bears, with both teams at 1-4, and for Colts vs. Jaguars, which each squad at 3-2. Lions vs. Buccaneers features a pair of one-loss teams, while Cowboys vs. Chargers have two-loss teams going head-to-head as you make your NFL confidence pool picks. With the records thrown out, what should your Week 6 NFL football pool picks hinge on? Recent trends, injuries and expected game flow should all be taken into account before setting NFL pool picks. Before you make your NFL predictions, you need to see the Week 6 NFL football pool picks from SportsLine's proven computer model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 5 of the 2023 NFL season on an incredible 171-119 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 25-11 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up. 

Now, the model has simulated the entire Week 6 NFL schedule 10,000 times and generated its optimal NFL pick'em plays. Head to SportsLine to see them now.

Top Week 6 NFL office pool predictions

One of the top Week 6 NFL predictions from the model: The Los Angeles Rams (-6) comfortably beat the Arizona Cardinals at home. L.A. has a decided health advantage after it got Cooper Kupp back last week, while Arizona just placed running back James Conner, who leads the team in scrimmage yards, on injured reserve. The Rams also have recent history in their favor since they are 11-2 versus Arizona since head coach Sean McVay took over in 2017.

This year, Los Angeles ranks in the top 10 in third-down conversion percentage and redzone offense. Its strengths should show up on Sunday since the Cardinals are a bottom-10 team in points allowed, yards allowed and third-down defense. The model foresees Rams quarterback Matthew Stafford taking advantage of the Cardinals' defense, as it projects him to have twice as many touchdown passes as interceptions. On the other side, Joshua Dobbs is forecasted to have more turnovers than TDs, and that helps L.A. win well over 60% of the time. See the rest of the model's Week 6 NFL pool picks here.

How to make Week 6 NFL office pool picks

The model also made the call on every other Week 6 NFL game and has strong picks for potentially close NFL matchups like Vikings vs. Bears, Seahawks vs. Bengals and Cowboys vs. Chargers. It's also calling for several favorites to struggle big-time. You can only see all of the model's NFL pool picks here.

So who should you pick in every Week 6 NFL game, and which favorites should you avoid? Visit SportsLine now to get optimal NFL office pool picks, all from a proven computer model that has returned over $7,000 since its inception, and find out.