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The No. 22 Michigan State Spartans will take on the Louisville Cardinals at 7:15 p.m. ET on Wednesday at the Jack Breslin Student Events Center as part of the ACC/Big Ten Challenge 2021. The Spartans are 5-2 overall and 2-0 at home, while U of L is 5-1 overall and hasn't played on the road yet. The two programs have met multiple times in the NCAA Tournament but most recently met during the regular season in 2018 with Louisville winning 82-78 as a five-point underdog.

That was Chris Mack's first season at the helm for Louisville but obviously Mack and MSU coach Tom Izzo have turned over their rosters since that matchup. This time around, the Spartans are favored by four points in the latest Michigan State vs. Louisville odds from Caesars Sportsbook and the over-under is set at 137.5. Before entering any Louisville vs. Michigan State picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $2,100 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Michigan State vs. Louisville. You can head to SportsLine to see its picks. Here are several college basketball odds for Louisville vs. Michigan State:

  • Michigan State vs. Louisville spread: Michigan State -4
  • Michigan State vs. Louisville over-under: 137.5 points

What you need to know about Michigan State

The contest between MSU and the Baylor Bears last week was not a total blowout, but with MSU falling 75-58, it was darn close to turning into one. The top scorers for MSU were forward Gabe Brown (13 points) and guard Jaden Akins (12 points). The loss ended a five-game winning streak following a season-opening loss to Kansas at Madison Square Garden.

During the winning streak, the Spartans had wins at Butler and then at a neutral site over Loyola Chicago and Connecticut before falling to Baylor in the Battle 4 Atlantis championship. No team shot better than 37.3 percent from the floor against Izzo's squad during the winning streak, so defensive intensity will be critical in another huge non-conference test against Louisville.

What you need to know about Louisville

Meanwhile, U of L was able to grind out a solid victory over the Maryland Terrapins this past Saturday, winning 63-55. Cardinals forward Malik Williams filled up the stat sheet, posting a double-double on 13 points and 12 rebounds. The Cardinals dominated the glass 44-23 in the win and also dominated Mississippi State on the glass 43-35 en route to winning the Bahamas Championship.

Williams is averaging 8.0 points and 9.8 rebounds per game and Louisville ranks 18th nationally in rebounds per game (42.8). However, Michigan State's loss to Baylor was the first time all season it had been outrebounded and it should be a fierce battle on the glass that could determine the outcome on Wednesday.

How to make Louisville vs. Michigan State picks

The model has simulated Michigan State vs. Louisville 10,000 times and the results are in. We can tell you that the model is leaning over and it's also generated a point-spread pick that is hitting in almost 60 percent of simulations. You can only see the pick at SportsLine.

So who wins Michigan State vs. Louisville? And which side of the spread hits almost 60 percent of the time? Visit SportsLine now to find out, all from the red-hot model that has crushed its college basketball picks.