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The No. 2 Notre Dame Fighting Irish are looking for a season sweep over the No. 3 Clemson Tigers when they meet in the 2020 ACC Championship Game on Saturday. The Fighting Irish (10-0) posted a 47-40 double overtime victory over the Tigers (9-1) last month at Notre Dame. With a win, the Fighting Irish would be positioned to claim a post in the College Football Playoff field. Notre Dame has won 11 national championships, the last coming in 1988. Clemson has won three national titles, including two of the last four.

Game time from Bank of America Stadium in Charlotte, N.C., is set for 4 p.m. ET. The Tigers are seventh nationally in total defense, allowing 302 yards per game, while the Fighting Irish are 14th, allowing 314.5. The Tigers are 10-point favorites in the latest Clemson vs. Notre Dame odds from William Hill Sportsbook, while the over-under for total points scored is set at 60. Before making any Notre Dame vs. Clemson picks, check out the college football predictions and betting advice from SportsLine's proven computer model. 

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past four-plus years, the proprietary computer model has generated a stunning profit of over $3,500 for $100 players on its top-rated college football picks against the spread. It is also a sizzling 54-34 on all top-rated picks through 15 weeks of the 2020 college football season, returning over $600. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Clemson vs. Notre Dame in the ACC Championship Game 2020. You can visit SportsLine now to see the picks. Here are the college football odds and trends for Notre Dame vs. Clemson:

  • Clemson vs. Notre Dame spread: Clemson -10
  • Clemson vs. Notre Dame over-under: 60 points
  • Clemson vs. Notre Dame money line: Clemson -430, Notre Dame +330
  • CLEM: Senior wide receiver Cornell Powell is attempting to catch a touchdown in four straight games for the first time in his career
  • ND: Has allowed just 17.1 points per game this season and ranks fifth among all Power 5 teams

Why Clemson can cover

Trevor Lawrence, who missed the first matchup against Notre Dame due to COVID-19, has some impressive options to work with. Senior Amari Rodgers is the Tigers' top receiver and leads the team with 61 receptions for 845 yards (13.9 average) and six touchdowns, including a long of 83 yards. He needs 155 yards to record the 12th 1,000-yard season in school history. He is 31 yards short of becoming the 15th player in Clemson history to reach 2,000 career receiving yards. He had eight receptions for 134 yards in the first game against the Irish. His best game was a 10-catch, 93-yard effort against Pittsburgh on Nov. 28.

Another receiver powering Clemson is Powell, who is tied for second on the team in receptions with running back Travis Etienne with 41 catches. Powell has 684 yards receiving, averaging 16.7 yards per catch with five touchdowns. He has had at least two catches in each game, including an 11-catch, 105-yard performance against Boston College on Oct. 31. He also had six receptions for 176 yards and a touchdown vs. Pittsburgh.

Why Notre Dame can cover

The Fighting Irish have dominated the opposition this year, with only two games decided by a touchdown or less -- 12-7 over Louisville on Oct. 17 and the game against Clemson. Senior Javon McKinley is Notre Dame's top receiver with 37 receptions for 660 yards (17.8 average) and three touchdowns. He has at least one catch in every game. His best outing was against Syracuse on Dec. 5 when he caught a season-high seven passes for 111 yards (15.9 average) and three scores.

Freshman tight end Michael Mayer has also made his mark on the offense. He has 30 receptions for 337 yards (11.2 average) and two touchdowns. He has had five catches in three games, including against the Tigers. Mayer has seen action in all 10 games, including two starts. Among all FBS true freshmen tight ends, Mayer ranks second in total receiving yards.

How to make Clemson vs. Notre Dame picks

SportsLine's model is leaning under on the total. In fact, it says Lawrence will be held to fewer than 270 yards and two touchdowns, while Book will be limited to under 200 yards passing and one touchdown. It has also generated an against-the-spread pick that cashes in well over 50 percent of simulations. You can only get the pick at SportsLine.

So who wins Notre Dame vs. Clemson? And which side of the spread cashes in well over 50 percent of simulations? Visit SportsLine now to see which side of the Clemson vs. Notre Dame spread to jump on, all from the advanced model that is up over $3,500 on its FBS college football picks over the past four-plus seasons, and find out.