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USATSI

The No. 23 Clemson Tigers will take on the South Carolina Gamecocks at 7:30 p.m. ET on Saturday at Williams-Brice Stadium. USC is 6-5 overall and 5-1 at home, while Clemson is 8-3 overall and 2-2 on the road. This in-state rivalry has had 117 previous meetings with Clemson leading the all-time series 71-42-4.

The Tigers are favored by 11.5 points in the latest South Carolina vs. Clemson odds from Caesars Sportsbook, and the over-under is set at 43. Before entering any Clemson vs. South Carolina picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Week 13 of the 2021 season on a 39-25 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on South Carolina vs. Clemson. You can head to SportsLine to see its picks. Here are several college football odds for South Carolina vs. Clemson:

  • South Carolina vs. Clemson spread: Clemson -11.5
  • South Carolina vs. Clemson over-under: 43 points

What you need to know about South Carolina

It was all tied up 14-14 at the half for the Gamecocks and the Auburn Tigers on Saturday, but USC stepped up in the second half for a 21-17 win. The victory came about thanks to a strong surge after the first quarter to overcome a 14-0 deficit. USC's RB ZaQuandre White looked sharp as he had 168 yards from scrimmage plus a receiving TD.

Eight different players have attempted a pass for South Carolina this year but the school has settled on Jason Brown over the last few games. A transfer from FCS program St. Francis, Brown has thrown multiple touchdowns in each of his last three games. His top target is senior WR Josh Vann who ranks among the top 10 in the SEC in receiving yards (630), receiving TDs (six) and yards per reception (16.2).

What you need to know about Clemson

Meanwhile, everything went Clemson's way against the Wake Forest Demon Deacons on Saturday as it made off with a 48-27 victory. The contest was all but wrapped up at the end of the third, by which point Clemson had established a 38-13 advantage. Running back Kobe Pace was on fire, rushing for two TDs and 191 yards on 24 carries.

QB D.J. Uiagalelei hasn't been able to pick up where Trevor Lawrence left off as he has nearly as many interceptions (eight) as he has touchdown passes (nine). But the Tigers have managed to win eight games thanks to their excellent defense which ranks eighth in the nation with 16.4 points allowed per game. The defensive effort is led by sixth-year senior LB James Skalski, who leads Clemson with 79 tackles, and sophomore DE Myles Murphy whose eight sacks rank fourth in the ACC.

How to make Clemson vs. South Carolina picks

The model is leaning under on the total, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Clemson vs. South Carolina? And which side of the spread has all the value? Visit SportsLine right now to see which side of the spread to back, all from the advanced model on a 39-25 run on its top-rated college football side picks, and find out.