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The Fresno State Bulldogs will take on the Oregon Ducks at 2 p.m. ET on Saturday at Autzen Stadium. Oregon is the No. 11 team in the AP Poll after winning the Pac-12 Championship Game last year over USC. Fresno State (1-0) destroyed UConn 45-0 in Week 0 and finished 3-3 last season, its first under coach Kalen DeBoer. These teams last met in 2012 when the Ducks won by a score of 42-25.

The Ducks are favored by 20.5 points in the latest Oregon vs. Fresno State odds from Caesars Sportsbook, and the over-under is set at 64. Before entering any Fresno State vs. Oregon picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of over $3,600 for $100 players on its top-rated college football picks against the spread. It also enters Week 1 of the 2021 season on a 57-37 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Oregon vs. Fresno State. You can head to SportsLine to see its picks. Here are several college football odds for Oregon vs. Fresno State:

  • Oregon vs. Fresno State spread: Oregon -20.5
  • Oregon vs. Fresno State over-under: 64 points

What you need to know about the Oregon Ducks 

Oregon will hand the reins of its offense to QB Anthony Brown, who is in his second year with the program after transferring from Boston College. Brown has lots of experience as he's attempted over 700 passes in college and brings great athleticism to the position as a dual-threat QB. Coaches haven't been afraid to even throw the ball to him on occasion as he has three receiving touchdowns in his career.

On the other side of the ball, the defense revolves around defensive end Kayvon Thibodeaux. The junior is projected by many to be the top overall pick in the 2022 NFL Draft after he was the top recruit coming out of high school. Thibodeaux has 12 sacks and 23.5 tackles for loss in just two seasons and was First-team All-Pac-12 last season.

What you need to know about the Fresno State Bulldogs

After losing its final two of the 2020 season, Fresno State got things started off on the right note by shutting out the UConn Huskies 45-0 last week. It was as lopsided a game as you'll see all year as the Bulldogs had five times as many yards as UConn, outgaining the Huskies 541-107. Quarterback Jake Haener completed 20-of-26 passes for 331 yards and three touchdowns, as 11 different Bulldogs finished with a catch.

Haener will be handing the ball off to running back Ronnie Rivers quite often as the fifth-year senior continues his climb up the Mountain West record books. Rivers ranks sixth all-time in conference history with 45 touchdowns from scrimmage and is top 15 in yards from scrimmage. He had 58 rushing yards, 66 receiving yards, one touchdown and even returned a punt in Week 0.

How to make Oregon vs. Fresno State picks

The model has simulated Fresno State vs. Oregon 10,000 times and the results are in. We can tell you that the model is leaning under, and it's also generated a point-spread pick that hits in well over 60 percent of simulations. You can only see the pick at SportsLine.

So who wins Fresno State vs. Oregon? And which side of the spread hits well over 60 percent of the time? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.