Fantasy Football Week 6 running back rankings: Sunday morning update for injuries and inactives

Chris Towers ranks the running backs for Week 6

Depending on how you count it, you could argue up to half the league has already had a change in lead running back since Week 1, either due to injury, demotion, or some other factor. Add in that the Saints, Falcons, Jets, and 49ers are on bye in Week 6 -- so no Alvin Kamara, Mike Davis Cordarrelle Patterson, Michael Carter, or Elijah Mitchell -- and the position looks even shallower than usual this week. And on Friday afternoon, we found out Nick Chubb (calf) and Christian McCaffrey (hamstring) aren't playing Sunday. The hits just keep coming.

Kareem Hunt vaults into the top 10 at running back and lands at No. 5 for me, with the expectation that he should be good for nearly 20 carries and a healthy passing game workload. D'Ernest Johnson also figures to see some run, and Demetric Felton could be a sneaky PPR play if they decide to use Hunt more like they do Chubb and Felton sees more snaps in passing situations. But you'll want Hunt in your lineup, obviously. 

As for McCaffrey's replacement, we know it'll be Chuba Hubbard, and his play so far has been a bit of a mixed bag. In Hubbard's first start, he ceded a bunch of valuable passing game work and had a really disappointing performance despite 15 carries. In his second, he carried the ball 24 times and had six targets. Let's call it in the middle and call him pretty much a must-start Fantasy RB, ahead of all of the waiver-wire adds like Khalil Herbert, Darrel Williams, and Devontae Booker this week. 

Get your first look at the running back rankings for Week 6 from Chris Towers, including thoughts on some of the most interesting players for this week. To see Jamey Eisenberg, Dave Richard, and Heath Cummings' rankings, make sure you head here. We'll be updating this throughout the week with new notes and rankings as we get news and the rankings get tweaked, so make sure you bookmark the page.    

Week 6 RB Rankings

1. Najee Harris vs. SEA
2. Derrick Henry vs. BUF
3. Austin Ekeler @ BAL
4. Kareem Hunt vs. ARI
5. Aaron Jones @ CHI
6. D'Andre Swift vs. CIN
7. Joe Mixon @ DET
8. Ezekiel Elliott @ NE
9. Dalvin Cook @ CAR
10. James Robinson vs. MIA
11. Darrell Henderson @ NYG
12. Jonathan Taylor vs. HOU
13. Chuba Hubbard vs. MIN
14. Chase Edmonds @ CLE
15. Antonio Gibson vs. KC
16. Josh Jacobs @ DEN
17. Khalil Herbert vs. GB
18. Alex Collins @ PIT
19. Devontae Booker vs. LAR
20. Leonard Fournette @ PHI
21. Myles Gaskin @ JAX
22. Darrel Williams @ WAS
23. J.D. McKissic vs. KC
24. Melvin Gordon vs. LV
25. Jamaal Williams vs. CIN
26. Miles Sanders vs. TB
27. Tony Pollard @ NE
28. Zack Moss @ TEN
29. Nyheim Hines vs. HOU
30. Javonte Williams vs. LV
31. Devin Singletary @ TEN
32. Damien Harris vs. DAL
33. Brandon Bolden vs. DAL
34. Giovani Bernard @ PHI
35. James Conner @ CLE
36. Kenneth Gainwell vs. TB
37. AJ Dillon @ CHI
38. Latavius Murray vs. LAC
39. Jerick McKinnon @ WAS
40. David Johnson @ IND
41. Mark Ingram @ IND
42. Alexander Mattison @ CAR
43. Kenyan Drake @ DEN
44. Jeremy McNichols vs. BUF
45. Sony Michel @ NYG
46. Royce Freeman vs. MIN
47. D'Ernest Johnson vs. ARI
48. Devonta Freeman vs. LAC
49. Ronald Jones @ PHI
50. Phillip Lindsay @ IND
51. Malcolm Brown @ JAX
52. Carlos Hyde vs. MIA
53. Deejay Dallas @ PIT
54. Salvon Ahmed @ JAX
55. Larry Rountree @ BAL
56. Peyton Barber @ DEN
57. Marlon Mack vs. HOU
58. Justin Jackson @ BAL
59. Rhamondre Stevenson vs. DAL
60. J.J. Taylor vs. DAL

So who should you start and sit this week? And which surprising quarterback could lead you to victory? Visit SportsLine now to get Week 6 rankings for every position, plus see which QB is going to come out of nowhere to crack the top 10, all from the model that has out-performed experts big-time.