| 1 | Kareem Hunt KC (at OAK) | Devonta Freeman ATL (at NE) | Kareem Hunt KC (at OAK) |
| 2 | Le'Veon Bell PIT (vs CIN) | Le'Veon Bell PIT (vs CIN) | Le'Veon Bell PIT (vs CIN) |
| 3 | Ezekiel Elliott DAL (at SF) | Ezekiel Elliott DAL (at SF) | Ezekiel Elliott DAL (at SF) |
| 4 | Mark Ingram NO (at GB) | Jordan Howard CHI (vs CAR) | LeSean McCoy BUF (vs TB) |
| 5 | Devonta Freeman ATL (at NE) | Kareem Hunt KC (at OAK) | Todd Gurley LAR (vs ARI) |
| 6 | LeSean McCoy BUF (vs TB) | Todd Gurley LAR (vs ARI) | Devonta Freeman ATL (at NE) |
| 7 | Jay Ajayi MIA (vs NYJ) | Doug Martin TB (at BUF) | Mark Ingram NO (at GB) |
| 8 | Todd Gurley LAR (vs ARI) | Mark Ingram NO (at GB) | Melvin Gordon LAC (vs DEN) |
| 9 | Jordan Howard CHI (vs CAR) | LeSean McCoy BUF (vs TB) | Jay Ajayi MIA (vs NYJ) |
| 10 | Carlos Hyde SF (vs DAL) | Jay Ajayi MIA (vs NYJ) | Jordan Howard CHI (vs CAR) |
| 11 | Jerick McKinnon MIN (vs BAL) | Jerick McKinnon MIN (vs BAL) | Jerick McKinnon MIN (vs BAL) |
| 12 | Adrian Peterson ARI (at LAR) | Adrian Peterson ARI (at LAR) | Carlos Hyde SF (vs DAL) |
| 13 | Melvin Gordon LAC (vs DEN) | Melvin Gordon LAC (vs DEN) | Doug Martin TB (at BUF) |
| 14 | C.J. Anderson DEN (at LAC) | DeMarco Murray TEN (at CLE) | C.J. Anderson DEN (at LAC) |
| 15 | Doug Martin TB (at BUF) | Carlos Hyde SF (vs DAL) | LeGarrette Blount PHI (vs WAS) |
| 16 | Chris Ivory JAC (at IND) | C.J. Anderson DEN (at LAC) | Alvin Kamara NO (at GB) |
| 17 | DeMarco Murray TEN (at CLE) | Christian McCaffrey CAR (at CHI) | DeMarco Murray TEN (at CLE) |
| 18 | Christian McCaffrey CAR (at CHI) | Tevin Coleman ATL (at NE) | Joe Mixon CIN (at PIT) |
| 19 | Tevin Coleman ATL (at NE) | Chris Ivory JAC (at IND) | Chris Ivory JAC (at IND) |
| 20 | Alvin Kamara NO (at GB) | Joe Mixon CIN (at PIT) | Chris Thompson WAS (at PHI) |
| 21 | Chris Thompson WAS (at PHI) | Alvin Kamara NO (at GB) | Marshawn Lynch OAK (vs KC) |
| 22 | Joe Mixon CIN (at PIT) | LeGarrette Blount PHI (vs WAS) | Adrian Peterson ARI (at LAR) |
| 23 | LeGarrette Blount PHI (vs WAS) | Chris Thompson WAS (at PHI) | Tevin Coleman ATL (at NE) |
| 24 | Derrick Henry TEN (at CLE) | Marshawn Lynch OAK (vs KC) | Christian McCaffrey CAR (at CHI) |
| 25 | James White NE (vs ATL) | Duke Johnson CLE (vs TEN) | Isaiah Crowell CLE (vs TEN) |
| 26 | Wendell Smallwood PHI (vs WAS) | Orleans Darkwa NYG (vs SEA) | Alex Collins BAL (at MIN) |
| 27 | Marshawn Lynch OAK (vs KC) | Matt Forte NYJ (at MIA) | Frank Gore IND (vs JAC) |
| 28 | Duke Johnson CLE (vs TEN) | Derrick Henry TEN (at CLE) | Duke Johnson CLE (vs TEN) |
| 29 | Orleans Darkwa NYG (vs SEA) | Wendell Smallwood PHI (vs WAS) | Orleans Darkwa NYG (vs SEA) |
| 30 | Javorius Allen BAL (at MIN) | Dion Lewis NE (vs ATL) | Ty Montgomery GB (vs NO) |
| 31 | Ty Montgomery GB (vs NO) | Marlon Mack IND (vs JAC) | Derrick Henry TEN (at CLE) |
| 32 | Dion Lewis NE (vs ATL) | James White NE (vs ATL) | Matt Forte NYJ (at MIA) |
| 33 | Rob Kelley WAS (at PHI) | Frank Gore IND (vs JAC) | Aaron Jones GB (vs NO) |
| 34 | Frank Gore IND (vs JAC) | Rob Kelley WAS (at PHI) | Javorius Allen BAL (at MIN) |
| 35 | Thomas Rawls SEA (at NYG) | Mike Gillislee NE (vs ATL) | Rob Kelley WAS (at PHI) |
| 36 | Marlon Mack IND (vs JAC) | Thomas Rawls SEA (at NYG) | Dion Lewis NE (vs ATL) |
| 37 | Aaron Jones GB (vs NO) | Jamaal Charles DEN (at LAC) | James White NE (vs ATL) |
| 38 | Matt Forte NYJ (at MIA) | Javorius Allen BAL (at MIN) | Mike Gillislee NE (vs ATL) |
| 39 | Alex Collins BAL (at MIN) | Alex Collins BAL (at MIN) | Marlon Mack IND (vs JAC) |
| 40 | Mike Gillislee NE (vs ATL) | Aaron Jones GB (vs NO) | Jamaal Charles DEN (at LAC) |
| 41 | Jonathan Stewart CAR (at CHI) | Isaiah Crowell CLE (vs TEN) | Thomas Rawls SEA (at NYG) |
| 42 | Isaiah Crowell CLE (vs TEN) | Ty Montgomery GB (vs NO) | Jonathan Stewart CAR (at CHI) |
| 43 | Jamaal Charles DEN (at LAC) | Giovani Bernard CIN (at PIT) | Eddie Lacy SEA (at NYG) |
| 44 | Tarik Cohen CHI (vs CAR) | Tarik Cohen CHI (vs CAR) | Bilal Powell NYJ (at MIA) |
| 45 | Bilal Powell NYJ (at MIA) | Jonathan Stewart CAR (at CHI) | Tarik Cohen CHI (vs CAR) |
| 46 | Eddie Lacy SEA (at NYG) | Bilal Powell NYJ (at MIA) | Andre Ellington ARI (at LAR) |
| 47 | Latavius Murray MIN (vs BAL) | Eddie Lacy SEA (at NYG) | Samaje Perine WAS (at PHI) |
| 48 | Giovani Bernard CIN (at PIT) | Samaje Perine WAS (at PHI) | Latavius Murray MIN (vs BAL) |