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The New York Jets look to secure their first win of the season when they square off against the Indianapolis Colts on Sunday afternoon. The Jets enter Sunday's contest averaging just 15 points per game, which ranks 31st in the NFL. The Colts, meanwhile, are looking for their second straight victory after knocking off the Vikings last week. 

Kickoff for Jets vs. Colts is set for 4:05 p.m. ET. Indianapolis is favored by 11.5-points in the latest Colts vs. Jets odds from William Hill, and the over-under is set at 44. Before entering any Jets vs. Colts picks, you'll want to see the NFL predictions from the advanced computer model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up over $7,300 for $100 players on its top-rated NFL picks since its inception five-plus years ago. It's off to a strong 5-2 roll on top-rated NFL picks this season. The model enters Week 3 on an incredible 101-67 roll on top-rated NFL picks that dates back to the 2017 season. 

The model also ranked in the Top 10 on NFLPickWatch in three of the past four years on straight-up NFL picks and beat more than 95 percent of CBS Sports office pool players three times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Colts vs. Jets. You can head to SportsLine to see its picks. Here are several NFL betting lines for Jets vs. Colts:

  • Colts vs. Jets spread: Colts -11.5
  • Colts vs. Jets over-under: 44 points
  • Colts vs. Jets money line: Indianapolis -600, New York 450

Why the Colts can cover

Through the first two weeks of the season, the Colts feature the NFL's most stingiest defense. In fact, Indianapolis' defense is giving up just 208 yards per game on average. Last week against the Vikings, the Colts forced Kirk Cousins to throw three interceptions while giving up just 113 passing yards. 

The Colts have also been sensational at Lucas Oil Stadium over the years, winning 12 of their last 15 home games. The Jets, meanwhile, are just 3-13 in their last 16 games on the road. 

What you need to know about the Jets

New York lost 31-13 at home to San Francisco. Sam Darnold completed 21 of 32 passes for 179 yards and a TD. Frank Gore led the Jets with 63 rushing yards. Braxton Berrios had a career-high six catches for 59 yards and his first career TD in Week 2.

Berrios will have to continue to step up along with Chris Hogan (six receptions for 75 yards last week) because the team's two top wide receivers are out. Jamison Crowder (hamstring) and Breshad Perriman (ankle) will not play vs. the Colts. Le'Veon Bell is on injured reserve with a hamstring injury. 

How to make Colts vs. Jets picks

SportsLine's model has simulated Colts vs. Jets 10,000 times and the results are in. The model is leaning over, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Jets vs. Colts? And which side of the spread hits in well over 50 percent of simulations? Visit SportsLine now to see which side of the Colts vs. Jets spread to jump on Sunday, all from the model that enters Week 3 of the NFL season on an incredible 101-67 roll.