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AFC West foes meet up on Monday Night Football as Patrick Mahomes and the the Kansas City Chiefs (3-1) host the Las Vegas Raiders (1-3) to wrap up the Week 5 NFL schedule. Kansas City beat the Tampa Bay Buccaneers 41-31 last week. On the other side, Las Vegas outmatched the Denver Broncos 32-23. Both teams enter this matchup in relatively good health. The Chiefs have ruled only kicker Harrison Butker (ankle) out while guard Trey Smith (pectoral), receiver JuJu Smith-Schuster (quad/hamstring) and defensive end Mike Danna are questionable. Jayon Brown (hamstring) is out for Las Vegas, while corner Sam Webb (hamstring) and tight end Foster Moreau (knee) are questionable. 

Kickoff is 8:15 p.m. ET at Arrowhead Stadium in Kansas City. Caesars Sportsbook lists Kansas City as the 7-point favorite in the latest Chiefs vs. Raiders odds set by Caesars Sportsbook. The over/under for total points is 51.5. Before finalizing any Raiders vs. Chiefs picks, be sure to see the NFL predictions from SportsLine's Larry Harstein.

A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed while working for Pro Football Focus. Entering the 2022 NFL season, he is 427-344 all-time on NFL side picks (plus $3,764 for $100 players), including 394-330 against the spread. Hartstein went 68-50 ATS (58%) and 8-3 on money-line plays last season for a profit of $1,552. He's also a sizzling 24-10 on his last 34 spread picks involving the Chiefs. Anybody who has been following him is way up.

Now, Hartstein has set his sights on Chiefs vs. Raiders and just locked in his picks and MNF predictions. You can head to SportsLine to see his picks. Now, here are several NFL odds and betting lines for Raiders vs. Chiefs

  • Chiefs vs. Raiders spread: Kansas City -7
  • Chiefs vs. Raiders over/under: 51.5 points
  • Chiefs vs. Raiders money line: Kansas City -355, Las Vegas +278
  • LV: Under is 5-1 in the Raiders' last six games following an ATS win
  • KC: Chiefs are 7-1-1 ATS in their last nine Monday games
  • Chiefs vs. Raiders picks: See picks here

Why the Chiefs can cover

Clyde Edwards-Helaire is the lead tailback in the backfield for Kansas City. Edwards-Helaire is a powerful runner with terrific lower-body strength. The LSU product has superb balance, vision and short-area explosiveness. He can also be a reliable receiving option coming out of the backfield. Edwards-Helaire leads the team with 41 carries for 208 yards and two touchdowns. The 2020 first-round pick has reeled in 13 passes for 117 yards and another three touchdowns.

Receiver Marquez Valdes-Scantling is a big-play threat for this offense who has helped fill the void left by Tyreek Hill. Valdes-Scantling owns blazing speed to blow past defenders with good ball-tracking skills. The USF product stands tall (6-foot-4) to out-leap defenders. He's snagged 13 passes for 168 yards thus far. In his last outing, he caught three receptions for a season-high 63 yards.

Why the Raiders can cover

Las Vegas has several players on its defensive front who can wreak havoc on the game. Their pass rush is headlined by Maxx Crosby. Crosby has developed into one of the best edge rushers in the game. The Eastern Michigan product owns an array of moves to beat tackles with speed and finesse. Crosby has 27 total tackles with a team-high four sacks and eight TFLs.

Linebacker Chandler Jones plays on the opposite side of Crosby. Jones has had a slow start to the season but is still a premier force coming off the edge. The Syracuse product owns the power and pass-rush plan to get past blockers. Linebacker Divine Deablo has exceptional size and speed in the middle of the defense. Deablo fills up gaps and quickly closes up lanes. The 2021 third-round pick is first on the team with 38 total stops. 

How to make Chiefs vs. Raiders picks

Hartstein has analyzed this matchup and he's leaning Over on the point total. He's also discovered a critical X-factor that has him jumping all over one side of the spread. He's only sharing what it is, and which side to back, at SportsLine.

Who wins Raiders vs. Chiefs on Monday Night Football? And which critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see which side of the Chiefs vs. Raiders spread to back, all from the expert who is an incredible 24-10 on picks involving Kansas City, and find out.