The Indianapolis Colts will take on the Los Angeles Rams at 1 p.m. ET on Sunday at Lucas Oil Stadium. The Rams rolled to a 34-14 road victory in their season opener vs. the Bears. The Colts took a 28-16 home loss to the Seahawks in Week 1. 

The Rams have won the last two meetings between the teams. Los Angeles is favored by 3.5 points in the latest Colts vs. Rams odds from Caesars Sportsbook, and the over-under is set at 48. Before entering any Rams vs. Colts picks, you'll want to see the NFL predictions from the model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 2 of the 2021 season on an incredible 121-79 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the Top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP    

Now, the model has set its sights on Colts vs. Rams. You can head to SportsLine to see its picks. Here are several NFL betting lines for Rams vs. Colts:

  • Colts vs. Rams spread: Rams -3.5
  • Colts vs. Rams over-under: 48 points
Featured Game | Indianapolis Colts vs. Los Angeles Rams

What you need to know about the Rams

Matthew Stafford passed for three TDs and 321 yards on 26 attempts in his Rams debut vs. the Bears. He threw a 67-yard TD pass to Van Jefferson in the first quarter. Stafford finished the game with a career-high 156.1 rating. He has 300-plus yards with two-plus TD passes in his last three matchups with the Colts. 

Cooper Kupp finished with seven catches for 108 yards last week, his 12th-career 100 yard game, and he scored his 25th career receiving TD. Kupp had five-plus receptions in seven of eight road games last season. Aaron Donald had nine sacks and three forced fumbles in eight road games last year.

What you need to know about the Colts

Carson Wentz passed for two TDs and 251 yards on 38 attempts in his Colts debut vs. Seattle. Zach Pascal caught both TD passes and has scored in three of his past four games. WRs Michael Pittman Jr. (ankle) and Parris Campbell (abdomen) are listed as questionable for Week 2. 

Tackle Braden Smith (foot) and cornerback Xavier Rhodes (calf) have been ruled out for Sunday's game. Jonathan Taylor had a career-high six receptions and 116 scrimmage yards vs. the Seahawks. Nyheim Hines had 82 scrimmage yards. 

How to make Rams vs. Colts picks

The model has simulated Colts vs. Rams 10,000 times and the results are in. The model is leaning under on the total, and it's also generated a point-spread pick that is hitting in over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Rams vs. Colts? And which side of the spread hits more than 50 percent of the time? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks.