Offensive Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Quarterback | T. Taylor Tyrod Taylor | E. Stick Easton Stick | — |
| Running Back | M. Gordon Melvin Gordon | J. Jackson Justin Jackson | — |
| Wide Receiver | K. Allen Keenan Allen | M. Williams Mike Williams | |
| Tight End | H. Henry Hunter Henry | V. Green Virgil Green | |
| Left Tackle | — | T. Scott Trent Scott | — |
| Left Guard | D. Feeney Dan Feeney | — | — |
| Center | S. Quessenberry Scott Quessenberry | — | — |
| Right Tackle | S. Tevi Sam Tevi | T. Pipkins Trey Pipkins | — |
Defensive Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Left Defensive End | J. Bosa Joey Bosa | I. Rochell Isaac Rochell | — |
| Right Defensive End | M. Ingram Melvin Ingram | — | — |
| Left Defensive Tackle | J. Jones Justin Jones | J. Tillery Jerry Tillery | |
| Right Defensive Tackle | — | P. Johnson P.J. Johnson | — |
| Strongside Linebacker | K. White Kyzir White | M. Jefferson Malik Jefferson | — |
| Middle Linebacker | D. Perryman Denzel Perryman | D. Tranquill Drue Tranquill | — |
| Weakside Linebacker | — | U. Nwosu Uchenna Nwosu | — |
| Right Cornerback | C. Hayward Casey Hayward | D. King Desmond King | |
| Left Cornerback | — | M. Davis Michael Davis | — |
| Strong Safety | D. James Derwin James | R. Teamer Roderic Teamer | — |
| Free Safety | R. Jenkins Rayshawn Jenkins | J. Watkins Jaylen Watkins | — |
Special Teams Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Punter | T. Long Ty Long | — | — |
| Kicker | M. Badgley Mike Badgley | — | — |
| Holder | T. Long Ty Long | T. Taylor Tyrod Taylor | — |
| Punt Returner | D. King Desmond King | — | — |
| Kick Returner | D. King Desmond King | T. Benjamin Travis Benjamin |