|Curtis Lazar (RW)||Upper Body||11-03-2021Expected to be out until at least Nov 4|
|Petr Mrazek (G)||Groin||10-15-2021Day-to-Day|
|Auston Matthews (C)||Wrist||10-17-2021Expected to be out until at least Oct 18|
|Ilya Mikheyev (RW)||Thumb||12-06-2021Expected to be out until at least Dec 7|
|Joseph Woll (G)||Undisclosed||10-17-2021Expected to be out until at least Oct 18|
|Alex Steeves (LW)||Shoulder||10-17-2021Expected to be out until at least Oct 18|
All times are US/Eastern.