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The Florida State Seminoles can move a step closer to their first Final Four appearance in 49 years when they square off with the Michigan Wolverines in a Sweet 16 matchup of the 2021 NCAA Tournament. The Seminoles (18-6), Gonzaga and Michigan are the only teams in the field to make three consecutive Sweet 16 appearances. Michigan (22-4) has lost in the Round of 16 in two of the last three NCAA Tournaments, the lone exception being its run to the national title game three years ago. 

Tip-off is at 5 p.m. ET on CBS from Bankers Life Fieldhouse. The winner advances to an Elite Eight matchup against either Alabama or UCLA. William Hill Sportsbook lists the Wolverines as two-point favorites, while the over-under for total points scored is 142.5 in the latest Michigan vs. Florida State odds. Before making any Florida State vs. Michigan picks, check out the college basketball predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past four-plus years, the proprietary computer model has generated an impressive profit of $2,200 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Michigan vs. FSU in the Sweet 16 of the NCAA Tournament 2021. You can head to SportsLine to see its picks. Here are several college basketball odds and trends for FSU vs. Michigan:

  • Michigan vs. FSU spread: Michigan -2
  • Michigan vs. FSU over-under: 142.5 points
  • Michigan vs. FSU money line: Michigan -140; Florida State +120
  • MICH: The Wolverines' 20 NCAA wins since 2013 are the most of any school
  • FSU: The Seminoles receive an average of 30.6 points from their bench

Why Michigan can cover 

Despite the absence of second-leading scorer Isaiah Livers (foot), the Wolverines have five players averaging in double figures in the NCAA Tournament. Freshman center Hunter Dickinson is shooting 10-of-14 in the tournament and posted his sixth double-double of the season with 12 points and 11 boards vs. LSU the last time out. Eli Brooks is coming off a 21-point game and is 8-for-15 from the 3-point line in the last two contests.

Sophomore Franz Wagner continues to do it all for Michigan, averaging 12.0 points, 8.0 boards and 4.0 assists in the tournament. The Wolverines have converted at least 20 free throws in each of their two NCAA wins and the ability to get to the line could be crucial against an opponent that has struggled to stay out of foul trouble. Michigan also has played outstanding perimeter defense, holding North Texas and LSU to a combined 7-of-33 from 3-point range.

Why Florida State can cover

The Seminoles come at teams in waves with a rotation that goes at least nine-deep and features four double-digit scorers that average between 12.3 and 10.2 points per game. Two of those top scorers, guards M.J. Walker and Scottie Barnes, have combined for a total of only 21 points through the first two rounds. Florida State has not needed big offensive contributions from them due to a defense that has held both opponents under 55 points while forcing 26 turnovers.

Anthony Polite has picked up the slack by scoring in double figures for three straight games, including a season-high 22 points while hitting four 3-pointers vs. Colorado in the Round of 32. The Seminoles, listed as the tallest team in Division I per kenpom.com, will try to counter Michigan center Hunter Dickinson with 7-foot-1 Balsa Koprivica and RaiQuan Gray. The 6-8, 260-pound Gray is averaging 13.0 points and 6.5 boards in the NCAA Tournament.

How to make Florida State vs. Michigan picks

The model is leaning over on the total, projecting the teams to combine for 147 points. It also says one side of the spread hits over 50 percent of the time. You can only see the pick at SportsLine.

So who wins FSU vs. Michigan? And which side of the spread hits over 50 percent of the time? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks.