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Two teams with College Football Playoff aspirations square off on Sunday when the No. 5 LSU Tigers and No. 8 Florida State Seminoles collide at Camping World Stadium in Orlando. Last season, the Tigers won the SEC West but fell to eventual national champion Georgia in the SEC Championship Game. LSU finished the season 10-4 after blitzing Purdue, 63-7, in the Citrus Bowl. Meanwhile, the Seminoles ended last season on a six-game winning streak, capped by a victory over Oklahoma in the Cheez-It Bowl. Sunday's game is a rematch of last year's exciting season opener, which was won by Florida State. 

Kickoff is at 7:30 p.m. ET. The Tigers are 2-point favorites in the latest LSU vs. Florida State odds, while the over/under for total points scored is 56.5. Before you make any Florida State vs. LSU picks, you need to see the college football predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, the proprietary computer model has generated a stunning profit of almost $2,500 for $100 players on its top-rated college football picks against the spread. Anyone who has followed the model has seen huge returns.

Now, the model has set its sights on LSU vs. Florida State and just revealed its picks and predictions. You can visit SportsLine now to see the model's CFB picks. Here are several college football odds and trends for FSU vs. LSU:

  • LSU vs. Florida State spread: Tigers -2
  • LSU vs. Florida State over/under: 56.5 points
  • LSU vs. Florida State money line: Tigers -126, Seminoles +106
  • LSU: QB Jayden Daniels ranked ninth in the FBS in completion percentage (68.6) in 2022
  • FSU: The Seminoles ranked fourth in the country in passing yards allowed per game (165.4) last year
  • LSU vs. Florida State picks: See picks at SportsLine 

Why the Tigers can cover

LSU has a budding star on defense in Harold Perkins. A 6-foot-1, 220-pound sophomore from the greater Houston area, Perkins led the Tigers in tackles for loss (13), sacks (7.5) and quarterback hurries (14) last season. Based on his performance, he was named to the AP Preseason All-America first team entering the year.

In addition, LSU has experience in the offensive backfield. The Tigers return all of their rushing yards (1,583) and touchdowns (27) from their running backs from a year ago, led by Josh Williams (532 yards, six TDs) and Noah Cain (409, 10). LSU set a school record with 39 rushing TDs in 2022. See which team to pick here.

Why the Seminoles can cover

Florida State is one of the most experienced teams in the country. The Seminoles return 79% of their production from last season, which ranks third in the FBS, behind only Kansas and Missouri. Those returnees include 11 All-ACC selections and the ACC's Defensive Rookie of the Year (Patrick Payton).

In addition, Florida State added a key playmaker on the outside in the offseason in receiver Keon Coleman. A 6-foot-4 junior transfer from Michigan State, Coleman led the Spartans last season with 58 receptions for 798 yards and seven touchdowns. Both he and teammate Johnny Wilson were named to the watch list for the Biletnikoff Award, which goes to the nation's best receiver at the end of the year. See which team to pick here.

How to make LSU vs. Florida State picks

SportsLine's model is leaning Under on the point total, projecting the teams to combine for 51 points. The model also says one side of the spread hits in over 50% of simulations. You can see the model's pick only at SportsLine

So who wins Florida State vs. LSU, and which side of the spread hits more than 50% of the time? Visit SportsLine now to see which side of the spread you need to jump on, all from the model that has notched a profit of almost $2,500 on its top-rated college football spread picks, and find out.