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There are only two matchups between Top 25 teams on the Week 3 college football schedule. One unfolds in Eugene as the No. 25 Oregon Ducks (1-1) host the No. 12 BYU Cougars (2-0). The Ducks were trounced 49-3 by Georgia in Week 1 before bouncing back with a 70-14 win over Eastern Washington last week. The Cougars opened their season with a 50-21 win over South Florida, followed by a victory over then-No. 9 Baylor last week.

Kickoff is set for 3:30 p.m. ET. Caesars Sportsbook lists the Ducks at -3.5 in the latest Oregon vs. BYU odds. The over/under for total points is set at 58. Before making any BYU vs. Oregon picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,400 for $100 players on its top-rated college football picks against the spread. It enters Week 3 of the 2022 college football season on a 50-41 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Oregon vs. BYU. You can head to SportsLine to see its picks. Here are several college football odds for BYU vs. Oregon:

  • Oregon vs. BYU spread: Oregon -3.5
  • Oregon vs. BYU over/under: 58 points
  • Oregon vs. BYU picks: See picks here

Why Oregon can cover

It's the first year as a head coach for Dan Lanning, and the Ducks were certainly overwhelmed by Georgia, where Lanning was the defensive coordinator last year, in the opener. But that might lead to some undervaluing the Ducks as they look to find their footing going forward. 

Though the level of competition was a huge step down, Oregon dismantled Eastern Washington last week thanks in large part to quarterback Bo Nix completing 28 of 33 passes for 277 yards and five touchdowns. Additionally, the Ducks have been unbeatable at Autzen Stadium recently. They've won 20 straight overall and 29 straight against non-conference foes at their home venue.

Why BYU can cover

BYU has a ton of momentum heading into this matchup, as it blew out South Florida in Week 1 before taking down then-No. 9 Baylor in overtime last weekend. The Cougars are led by junior quarterback Jaren Hall, who has completed 48 of 71 passes for 522 yards and three touchdowns. They were without their top two wide receivers last week, but Puka Nacua (ankle) and Gunner Romney (undisclosed) are both listed as questionable for this game. 

Senior running back Christopher Brooks has rushed for 166 yards and one touchdown on 26 carries, averaging 6.4 yards per attempt. Freshman wide receiver Chase Roberts has stepped up with Nacua and Romney sidelined, catching 11 passes for 163 yards. The Cougars have won five of their last six road games and have covered the spread in four of their last five games as underdogs. 

How to make Oregon vs. BYU picks

The model has simulated BYU vs. Oregon 10,000 times and the results are in. It is leaning Under on the total, and it's also generated a point-spread pick that is hitting in almost 60% of simulations. You can only see the pick at SportsLine.

So who wins Oregon vs. BYU? And which side of the spread hits in almost 60% of simulations? Visit SportsLine now to find out which side of the BYU vs. Oregon spread you need to jump on Saturday, all from the model that has crushed its college football picks, and find out.