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Christian McCaffrey RB | SF
49ers' Christian McCaffrey: Two touchdowns in Week 6 win
McCaffrey rushed 16 times for 64 yards and two touchdowns and brought in nine of 10 targets for 53 yards in the 49ers' 23-17 win over the Commanders on Monday night. He also lost a fumble.
McCaffrey, who's been subject to a markedly lighter workload than usual over the first weeks of the campaign, recorded season highs in rush attempts, receptions, receptions and targets on a very busy night. The star running back also contributed his second multi-touchdown tally of the season, powering into the end zone on a pair of one-yard runs in the first half. McCaffrey logged twice as many carries and nine more targets than rookie backfield mate Kaelon Black, so there's no naturally no question who the leader of the ground attack is heading into a Week 7 road matchup against the Falcons on Sunday.
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Jaydon Blue RB | PHI
Eagles' Jaydon Blue: Doesn't play in Week 6
Blue did not play in Sunday's 25-14 loss to the Panthers.
Blue was signed to the Eagles' active roster ahead of Week 6, but the running back did not appear in the team's loss. Dameon Pierce handled all 12 of the team's carries and caught four of five targets for 15 yards while operating as the team's primary option in the backfield. If Saquon Barkley (hamstring) remains sidelined in Week 7, Blue will likely get another shot to make his Eagles debut versus Dallas.
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Isaiah Davis RB | NYJ
Jets' Isaiah Davis: Seven rushes in loss
Davis rushed seven times for 16 yards and caught his only target for 10 yards during Sunday's 26-19 loss to the Patriots.
Davis was on the field for just eight offensive snaps, but the running back had a touch on each of those snaps. Davis entered Week 6 having toted the rock just two times over five contests, so his increase in workload was a positive turn of events. With Breece Hall (quadriceps) still uncertain for Week 7, Davis could operate as the primary backup behind Braelon Allen again versus the Dolphins on Sunday.
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CJ Donaldson RB | NO
Saints' CJ Donaldson: Rushing TD reversed in Week 6 win
Donaldson logged six carries for 39 yards and lost a fumble during the Saints' 34-27 win over the Giants on Sunday. He also recorded three tackles (one solo) on special teams.
It appeared as though Donaldson found the end zone on a one-yard carry midway through the third quarter for what would have been the first touchdown of his NFL career. Unfortunately for the undrafted rookie, the call on the field was reversed, so it was quarterback Tyler Shough who snuck in for the touchdown on the next play. Donaldson proceeded to lose a fumble in the fourth quarter -- leading to a Giants touchdown six plays later -- and he didn't log another carry after that. Travis Etienne (hamstring, IR) has been sidelined for each of the Saints' last three games, and during that span, Donaldson has operated as the team's RB3 behind Alvin Kamara and Kendre Miller. The Saints will travel to Paris for a Week 7 tilt against the Steelers on Oct. 25.
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Josh Williams RB | TB
Josh Williams: Reverts to Tampa Bay's practice squad
Williams reverted to the Buccaneers' practice squad Monday, per the NFL's transaction log.
Williams was elevated as a precaution but did not play in the game, even though Sean Tucker (quadriceps) was inactive. Williams suited up to watch Bucky Irving and Kenny Gainwell absorb all of the offensive snaps. The running back also did not see any reps with the special teams unit in the contest.
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Devin Singletary RB | NYG
Giants' Devin Singletary: Gets first touches since Week 2
Singletary logged four carries into 14 yards and hauled in his lone target for 19 yards during Sunday's 34-27 loss to the Saints on Sunday.
Singletary was back in action Sunday after being a healthy scratch in each of the Giants' three games prior to Week 6. Three of his four carries went for two yards or fewer, although he did log a nine-yard rush and 19-yard catch on back-to-back plays early in the fourth quarter. Singletary's 31 offensive snaps were most among Giants running backs, but the team's backfield situation is a mess, given Cam Skattebo saw the field for only six offensive snaps and did not record a carry. The Giants will hit the road for Week 7 against the Texans on Oct. 25.
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Jawhar Jordan RB | HOU
Texans' Jawhar Jordan: Returns to Texans' practice squad
Jordan reverted to Houston's practice squad Monday, per the NFL's transaction log.
Jordan played 14 of the Texans' 63 offensive snaps in their 34-31 win over the Jaguars in London in Week 6, taking 6 carries for 43 yards and a touchdown and catching his only target for another seven yards. With regular starter David Montgomery (groin) out, Jordan proved an effective change of pace behind 2025 fourth-rounder Woody Marks. If Montgomery is out again in Week 7 versus the Giants, Jordan could be in line for another significant role come Sunday.
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Zavier Scott RB | CHI
Zavier Scott: Returns to practice squad
Scott reverted to Chicago's practice squad Monday, per the NFL's transaction report.
Scott was elevated as Kyle Monangai was out with a toe injury, but he ended up playing exclusively on special teams, logging three tackles and a forced fumble while in kick and punt coverage. This marked the second straight game that Scott was elevated, and he could play again in Thursday's matchup versus the Patriots if Monangai remains sidelined.
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Emmett Johnson RB | KC
Chiefs' Emmett Johnson: Five touches in Week 6 win
Johnson turned three carries into six yards and caught two of three targets for 18 yards during Sunday's 22-6 win over the Chargers. He also returned two kickoffs for 50 yards.
Johnson maintained his rotational role in the Chiefs' offense, with his 18 offensive snaps well behind Kenneth Walker's 45. Given Walker's tremendous start to the season, Johnson is one of the premier handcuff running backs in fantasy, and his scoring floor would rise significantly if the former ever missed time. The Chiefs will take their 5-0 record on the road for Week 7 against the Seahawks on Oct. 25.
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Anthony Tyus III RB | CAR
Anthony Tyus: Going back to practice squad
Tyus reverted to the Panthers' practice squad Monday, per the NFL's transaction log.
Tyus played two of Carolina's 79 offensive snaps and 13 snaps on special teams during Sunday's 25-14 win at Philadelphia, but he did not make any mark on the box score in Week 6. Whether the Panthers need his services again in Week 7 may depend on the availability of AJ Dillon (ankle).