The Week 1 NFL schedule has a bunch of exciting matchups, and one of them will be the Washington Commanders hosting the New York Giants. The Commanders finished last season with a 12-5 record and made it all the way to the NFC Championship Game. They ultimately lost to the Philadelphia Eagles, 55-23. Meanwhile, the Giants logged a 3-14 record in 2024, finishing last in the NFC East. Both teams retooled as the Giants added Russell Wilson in free agency and Abdul Carter in the NFL draft. The Commanders acquired Deebo Samuel from the San Francisco 49ers. 

Kickoff is scheduled for 1 p.m. ET at Northwest Stadium in Landover, MD. Washington is favored by 6 points in the latest Giants vs. Commanders odds, and the over/under is listed at 45.5 points. Both teams are filled with stars such as Jayden Daniels, Terry McLaurin, Malik Nabers, and Deebo Samuel, who could make for popular anytime touchdown NFL prop bets when online sports betting this matchup. Before making any Giants vs. Commanders picks or touchdown props at sportsbooks, be sure to see the Week 1 NFL predictions from SportsLine's proven model and see the latest NFL odds. They can also help new users take advantage of sportsbook promos like the latest Fanatics Sportsbook promo code. At Fanatics, you can bet anytime TDs and get $100 in FanCash plus $100 No Sweat Bets in FanCash every Game Day: 

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model went 31-15 on top-rated picks in 2024. 

Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns. Now, the model has revealed its top Giants vs. Commanders anytime touchdown prop picks: 

Best Week 1 Giants vs. Commanders anytime TD prop picks:

Jayden Daniels, Commanders 2+ passing touchdowns (-115)

The Commanders have Kliff Kingsbury on the sideline as offensive coordinator again and added more to that side of the ball. Washington traded for Laremy Tunsil and Deebo Samuel, joining the likes of Terry McLaurin and Zach Ertz. Last season, Jayden Daniels completed 69% of his passes for 3,568 yards and 25 passing touchdowns. He finished with two-plus passing touchdowns in eight regular-season games. 

In his second outing against New York, Daniels went 15-of-22 for 209 yards and two passing touchdowns. While this isn't your typical anytime touchdown scorer bet, the model projects Daniels to throw two touchdowns in this game. 

Malik Nabers, Giants (+150)

Nabers was one of the best receivers in the league last season, as he had 109 catches for 1,204 receiving yards and seven touchdowns. With better quarterback play expected under center, Nabers' production should improve, especially since he's the No.1 target. Last season, during the loss at Northwest Stadium, Nabers reeled in 10 passes for 127 receiving yards and one touchdown. SportsLine's model projects Nabers to finish with 84 receiving yards while scoring a touchdown in 70% of simulations, the highest on the team. 

Terry McLaurin, Commanders, (+130)

McLaurin has been the Commanders' best playmaker for the last six seasons, but last season was different. The Ohio State product had 82 catches for 1,096 receiving yards and a career-high 13 touchdowns. He tallied a touchdown in 12 games, including the playoffs. In his last outing against the Giants, McLaurin reeled in two touchdowns. The model predicts that McLaurin scores a touchdown in 70% of the simulations. 

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You've seen the model's NFL anytime touchdown prop picks for Giants vs. Commanders. Now, get NFL Week 1 projections for every NFL spread, total and player prop at SportsLine.

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You can also see the model's best bets for every Week 1 NFL game, including Chiefs vs. Chargers, Buccaneers vs. Falcons and Bears vs. Vikings. Finally, SportsLine expert Micah Roberts, who is 14-4-1 (+958) over his last 19 Packers ATS picks, has locked in a side for Lions vs. Packers. Visit SportsLine to see his pick.

Want more huge paydays? The model has also built a five-leg Week 1 NFL parlay that would pay 25-1. Check out the model's Week 1 NFL parlay only at SportsLine. Visit SportsLine to see the parlay.